2H-imidazol-4-amine compounds, therapeutically acceptable salts thereof, processes for preparation thereof, therapeutic uses of such compounds for treating Aβ-related pathologies such as Down's syndrome, β-amyloid angiopathy, Alzheimer's disease, memory loss, attention deficit symptoms associated with Alzheimer's disease, neurodegeneration associated with diseases such as Alzheimer's disease or dementia including dementia of mixed vascular and degenerative origin, pre-senile dementia, senile dementia and dementia associated with Parkinson's disease, progressive supranuclear palsy or cortical basal degeneration. methods of therapy, and pharmaceutical compositions containing such compounds.
2H-咪唑-4-胺化合物及其治疗上可接受的盐,其制备方法,治疗Aβ相关病理的治疗用途,例如唐氏综合征,β-淀粉样血管病,阿尔茨海默病,记忆力丧失,与阿尔茨海默病相关的注意力缺陷症状,与阿尔茨海默病或痴呆症等神经退行性疾病相关的神经退行性疾病,包括混合血管和退行性起源的痴呆症,早老性痴呆症,老年性痴呆症和与帕
金森病,进行性核上性麻痹或皮质基底节变性相关的痴呆症,治疗方法以及含有此类化合物的制药组合物。