3-(3-tert-butyl-isoxazol-5-yl)-5-[1-methyl-1-(tetrahydro-pyran-4-ylmethanesulfonyl)-ethyl]-[1,2,4]oxadiazole | 1196103-61-3

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: 3-(3-tert-butyl-isoxazol-5-yl)-5-[1-methyl-1-(tetrahydro-pyran-4-ylmethanesulfonyl)-ethyl]-[1,2,4]oxadiazole
• 英文别名: 3-(3-Tert-butyl-1,2-oxazol-5-yl)-5-[2-(oxan-4-ylmethylsulfonyl)propan-2-yl]-1,2,4-oxadiazole
• CAS: 1196103-61-3
• 化学式: C₁₈H₂₇N₃O₅S
• 分子量: 397.495
• InChiKey: RILFJUJNTRSNNA-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  27
• 可旋转键数：
  6
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.72
• 拓扑面积：
  117
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Sulfone compounds which modulate the CB2 receptor
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2418207A1

  公开（公告）日：2012-02-15

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  揭示了调节CB2受体的化合物。根据本发明的化合物结合并是CB2受体的激动剂，可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• Sulfone Compounds Which Modulate The CB2 Receptor
  申请人：Hickey Eugene Richard

  公开号：US20120015988A1

  公开（公告）日：2012-01-19

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  本发明揭示了调节CB2受体的化合物。根据本发明，这些化合物与CB2受体结合并激活它，可用于治疗炎症。其中的激动剂化合物还可用于治疗疼痛。
• SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2283001A2

  公开（公告）日：2011-02-16
• [EN] SULFONE COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR<br/>[FR] COMPOSÉS SULFONES QUI MODULENT LE RÉCEPTEUR CB2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2009140089A2

  公开（公告）日：2009-11-19

  Compounds which modulate the CB2 receptor are disclosed. Compounds according to the invention bind to and are agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.