2-Amino-6-(3,4-dichlorophenyl)-4-(4-methoxyphenyl)pyridine-3-carbonitrile | 106043-97-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-Amino-6-(3,4-dichlorophenyl)-4-(4-methoxyphenyl)pyridine-3-carbonitrile
• CAS: 106043-97-4
• 化学式: C₁₉H₁₃Cl₂N₃O
• 分子量: 370.238
• InChiKey: YAJUNKUTBISEFV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.05
• 拓扑面积：
  71.9
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  1-(2,4-dichlorophenyl)-3-(4-methoxyphenyl)prop-2-en-1-one 、 丙二腈 在 乙酸铵 作用下， 以 乙醇 为溶剂， 反应 6.0h， 以35%的产率得到2-Amino-6-(3,4-dichlorophenyl)-4-(4-methoxyphenyl)pyridine-3-carbonitrile
  参考文献：
  名称：

  Latif, N.; Mishriky, N.; Haggag, B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1230 - 1234

  摘要：

  DOI：

文献信息

• Synthesis of 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones and their 2-imino isosteres as nonsteroidal cardiotonic agents
  作者：Ashraf Abadi、Omar Al-Deeb、Ahmed Al-Afify、Hassan El-Kashef

  DOI：10.1016/s0014-827x(99)00004-x

  日期：1999.4

  Thirty new 1,2-dihydropyridine derivatives of the general formula 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-pyridinones (1-15) and 4-alkyl (aryl)-6-aryl-3-cyano-2(1H)-iminopyridines (16-30) were synthesized using one-pot multicomponent reactions of the properly substituted acetophenone, appropriate aldehyde, ammonium acetate and ethyl cyanoacetate (1-15) or malononitrile (16-30) in ethanol. These target compounds (1-30) were evaluated for their cardiotonic activity using the spontaneously beating atria model, from reserpine-treated guinea pigs. The best pharmacological profile was obtained with 3-cyano-6-(3,4-dimethoxyphenyl)-4-(4-hydroxyphenyl)-2(1H)-pyridinone (9) which displayed selectivity for increasing the force of contraction (108.7 +/- 6.7,% change over control) rather than the frequency rate (40.81 +/- 5.3,% change over control) at a 5 x 10(-4) M concentration. The effects of structural changes upon activity are reported. (C) 1999 Elsevier Science S.A. All rights reserved.
• LATIF N.; MISHRIKY N.; HAGGAG B.; BASYOUNI W., INDIAN J. CHEM., 24,(1985) N 12, 1230-1234
  作者：LATIF N.、 MISHRIKY N.、 HAGGAG B.、 BASYOUNI W.

  DOI：——

  日期：——
• Latif, N.; Mishriky, N.; Haggag, B., Indian Journal of Chemistry - Section B Organic and Medicinal Chemistry, 1985, vol. 24, p. 1230 - 1234
  作者：Latif, N.、Mishriky, N.、Haggag, B.、Basyouni, W.

  DOI：——

  日期：——