6-Chloro-2-oxo-3-(pyrazine-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid propylamide | 618903-13-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 6-Chloro-2-oxo-3-(pyrazine-2-carbonyl)-2,3-dihydro-indole-1-carboxylic acid propylamide
• 英文别名: 6-chloro-2-oxo-N-propyl-3-(pyrazine-2-carbonyl)-3H-indole-1-carboxamide
• CAS: 618903-13-2
• 化学式: C₁₇H₁₅ClN₄O₃
• 分子量: 358.784
• InChiKey: KYVCOYJRSUEMHS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  25
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.24
• 拓扑面积：
  92.3
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Selective inhibitors of cyclooxygenase-2
  申请人：Pfizer Inc.

  公开号：US20030207897A1

  公开（公告）日：2003-11-06

  The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula I: 1 pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the invention are particularly useful in the treatment or alleviation of inflammation and inflammation associated disorders, such as, for example, rheumatoid arthritis and osteoarthritis, and in the relief of pain, such as, for example, pain associated with surgery or trauma, in mammals, preferably felines and canines.

  本发明涉及公式I的环氧合酶-2（COX-2）选择性抑制剂，以及含有它们的药物组合物、它们的药用以及制备方法。本发明中的化合物特别适用于治疗或缓解炎症和与炎症相关的疾病，例如类风湿性关节炎和骨关节炎，并且可以缓解哺乳动物，尤其是猫和狗的手术或创伤相关的疼痛。
• INDOL-2-ONES AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2
  申请人：Pfizer Products Inc.

  公开号：EP1497280A1

  公开（公告）日：2005-01-19
• US6846818B2
  申请人：——

  公开号：US6846818B2

  公开（公告）日：2005-01-25
• [EN] INDOL-2-ONES AS SELECTIVE INHIBITORS OF CYCLOOXYGENASE-2<br/>[FR] INDOL-2-ONES UTILES EN TANT QU'INHIBITEURS SELECTIFS DE LA CYCLOOXYGENASE-2
  申请人：PFIZER PROD INC

  公开号：WO2003089427A1

  公开（公告）日：2003-10-30

  The present invention relates to cyclooxygenase-2 (COX-2) selective inhibitors of formula (I) pharmaceutical compositions containing them, to their medicinal use, and to their preparations. The compounds of the invention are particularly useful in the treatment or alleviation of inflammation and inflammation associated disorders, such as, for example, rheumatoid arthritis and osteoarthritis, and in the relief of pain, such as, for example, pain associated with surgery or trauma, in mammals. preferably felines and canines.