cis-[diammino (potassium 2-(4-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino)-4-(dicarboxymethyl-carbamoyl)-butyrato)platinum(II)] | 1016986-64-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cis-[diammino (potassium 2-(4-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino)-4-(dicarboxymethyl-carbamoyl)-butyrato)platinum(II)]
• CAS: 1016986-64-3
• 化学式: C₂₂H₂₅N₁₀O₉Pt*K
• 分子量: 807.68
• InChiKey: UZPVBCHFWHQSNY-UHFFFAOYSA-K

计算性质

• 辛醇/水分配系数(LogP)：
  None
• 重原子数：
  None
• 可旋转键数：
  None
• 环数：
  None
• sp3杂化的碳原子比例：
  None
• 拓扑面积：
  None
• 氢给体数：
  None
• 氢受体数：
  None

反应信息

• 作为产物：
  描述：

  二氨二碘铂 、 hydrogen dipotassium 2-(4-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino)-4-(dicarboxymethyl-carbamoyl)-butyrate 、 水 在 silver nitrate 作用下， 以 水 为溶剂， 以84%的产率得到cis-[diammino (potassium 2-(4-[(2-amino-4-oxo-3,4-dihydro-pteridin-6-ylmethyl)-amino]-benzoylamino)-4-(dicarboxymethyl-carbamoyl)-butyrato)platinum(II)]
  参考文献：
  名称：

  Stepwise assembly of platinum–folic acid conjugates

  摘要：

  Folates and folate-like molecules represent a class of vectors for drug targeting and delivery. The folate receptor (FR) is overexpressed in many human cancers, therefore folate-cytotoxic drug conjugates can deliver therapeutic agents specifically to FR positive tumours. We have linked, directly through one of the carboxylate functionalities of the folic acid ( alpha or gamma), two different chelating arms for a cytotoxic platinum moiety, namely a diamine and a dicarboxylate. Five different derivatives were synthesised by multi-step procedures, purified and characterised; unfortunately, they resulted barely soluble in water, thereby precluding any biochemical and biological tests. (c) 2007 Elsevier B. V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.09.020