3-tert-butyl-2-hydroxy-5-nitrobenzoic acid | 372137-84-3

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 3-tert-butyl-2-hydroxy-5-nitrobenzoic acid
• CAS: 372137-84-3
• 化学式: C₁₁H₁₃NO₅
• 分子量: 239.228
• InChiKey: GBKSYLVEHBNSOL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  17
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  103
• 氢给体数：
  2
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  3-tert-butyl-2-hydroxy-5-nitrobenzoic acid 在 氯化亚砜 作用下， 反应 1.0h， 生成
  参考文献：
  名称：

  Manganese amido-imine bisphenol Hangman complexes

  摘要：

  A modular ligand macrocycle is composed from two phenolic groups linked to a cyclohexane bridge through an amide bond and an imine bond. The stability of the asymmetric linkers to metathesis permits a macrocyclic platform to be assembled from the condensation of two different phenolic groups in a single-step, high yield, reaction. The primary coordination sphere may be tuned with functional groups on one phenolic group. The other phenolic group may be modified with a scaffold possessing a proton transfer group. In this way, control over the secondary coordination sphere of the macrocycle is achieved. Manganese complexes of the amido-imine linked macrocycle catalytically epoxidizes 1,2-dihydronapthalene using sodium hypochlorite as the oxidant. The amido-imine macrocycles represent a new metal active site capable of supporting high oxidation states and attendant atom transfer chemistry while at the same time permitting control over the primary and secondary sphere of the metal center. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.111
• 作为产物：
  描述：

  3-叔丁基-2-羟基-5-硝基苯甲醛 在 silver(l) oxide 作用下， 以 sodium hydroxide 为溶剂， 反应 16.0h， 以86%的产率得到3-tert-butyl-2-hydroxy-5-nitrobenzoic acid
  参考文献：
  名称：

  Manganese amido-imine bisphenol Hangman complexes

  摘要：

  A modular ligand macrocycle is composed from two phenolic groups linked to a cyclohexane bridge through an amide bond and an imine bond. The stability of the asymmetric linkers to metathesis permits a macrocyclic platform to be assembled from the condensation of two different phenolic groups in a single-step, high yield, reaction. The primary coordination sphere may be tuned with functional groups on one phenolic group. The other phenolic group may be modified with a scaffold possessing a proton transfer group. In this way, control over the secondary coordination sphere of the macrocycle is achieved. Manganese complexes of the amido-imine linked macrocycle catalytically epoxidizes 1,2-dihydronapthalene using sodium hypochlorite as the oxidant. The amido-imine macrocycles represent a new metal active site capable of supporting high oxidation states and attendant atom transfer chemistry while at the same time permitting control over the primary and secondary sphere of the metal center. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2008.05.111

文献信息

• A Practical Route to Regiospecifically Substituted (R)- and (S)-Oxazolylphenols
  作者：Andreas Scheurer、Paul Mosset、Walter Bauer、Rolf W. Saalfrank

  DOI：10.1002/1099-0690(200108)2001:16<3067::aid-ejoc3067>3.0.co;2-0

  日期：2001.8

  using the Appel reaction, whereas in route B the amino alcohols 13b−d were treated with the 2-hydroxybenzonitriles 4 and 6, under Witte−Seeliger conditions. The latter route was advantageous for L-valinol 13b and L-tert-leucinol 13c, while route A was the method of choice for the new, sterically demanding amino alcohol 13a, prepared from D- and L-serine. The nitro group in the salicylic derivatives

  从水杨酸衍生物 4-7 和各种对映异构纯 1,2-氨基醇 13a-d 开始，通过两条互补路线 A 和 B 制备了新的、不同取代的酚恶唑啉 14a-d 和 15a-d。在路线 A 中，使用 Appel 反应将 1,2-氨基醇 13a-d 与水杨酸 5 和 7 直接缩合，而在路线 B ​​中，氨基醇 13b-d 用 2-羟基苯甲腈 4 和 6 处理, 在 Witte-Seeliger 条件下。后一条路线有利于 L-缬氨醇 13b 和 L-叔亮氨醇 13c，而路线 A 是由 D-和 L-丝氨酸制备的新的、空间要求高的氨基醇 13a 的首选方法。水杨酸衍生物5和6中的硝基通过用硝酸对叔丁基进行区域特异性同位取代而引入。
• Manganese amido-imine bisphenol Hangman complexes
  作者：Jenny Y. Yang、Daniel G. Nocera

  DOI：10.1016/j.tetlet.2008.05.111

  日期：2008.8

  A modular ligand macrocycle is composed from two phenolic groups linked to a cyclohexane bridge through an amide bond and an imine bond. The stability of the asymmetric linkers to metathesis permits a macrocyclic platform to be assembled from the condensation of two different phenolic groups in a single-step, high yield, reaction. The primary coordination sphere may be tuned with functional groups on one phenolic group. The other phenolic group may be modified with a scaffold possessing a proton transfer group. In this way, control over the secondary coordination sphere of the macrocycle is achieved. Manganese complexes of the amido-imine linked macrocycle catalytically epoxidizes 1,2-dihydronapthalene using sodium hypochlorite as the oxidant. The amido-imine macrocycles represent a new metal active site capable of supporting high oxidation states and attendant atom transfer chemistry while at the same time permitting control over the primary and secondary sphere of the metal center. (C) 2008 Elsevier Ltd. All rights reserved.