| 1315501-25-7

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• CAS: 1315501-25-7
• 化学式: C₁₅H₁₇F₄N₃O₃
• 分子量: 363.312
• InChiKey: ZNODDZGPEHZRJU-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.13
• 重原子数：
  25.0
• 可旋转键数：
  11.0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.53
• 拓扑面积：
  95.29
• 氢给体数：
  1.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  、 溶血磷脂酰胆碱(鸡蛋) 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 氯仿 为溶剂， 反应 77.0h， 以31%的产率得到
  参考文献：
  名称：

  Photoactivatable Phospholipids Bearing Tetrafluorophenylazido Chromophores Exhibit Unprecedented Protonation-State-Dependent ¹⁹F NMR Signals

  摘要：

  Phospholipids bearing tetrafluorophenylazido chromophores were synthesized with perfectly conserved amphiphilicity and photochemical activity. Interestingly however, those phospholipids harboring the amine-linked chromophores exhibited unusual F-19 NMR signals which depended on the protonation state of the lipid headgroup. These probes may serve as powerful tools for studying various pH-dependent events in biomembranes.

  DOI：

  10.1021/ol201593k
• 作为产物：
  描述：

  苯甲醇,4-叠氮-2,3,5,6-四氟- 在 silver tetrafluoroborate 、 水 、 silver carbonate 、 sodium hydroxide 作用下， 以 甲醇 、 乙腈 为溶剂， 反应 77.0h， 生成
  参考文献：
  名称：

  Photoactivatable Phospholipids Bearing Tetrafluorophenylazido Chromophores Exhibit Unprecedented Protonation-State-Dependent ¹⁹F NMR Signals

  摘要：

  Phospholipids bearing tetrafluorophenylazido chromophores were synthesized with perfectly conserved amphiphilicity and photochemical activity. Interestingly however, those phospholipids harboring the amine-linked chromophores exhibited unusual F-19 NMR signals which depended on the protonation state of the lipid headgroup. These probes may serve as powerful tools for studying various pH-dependent events in biomembranes.

  DOI：

  10.1021/ol201593k