2-(3-aminopyrazolo[1,5-a]pyridin-2-yloxy)ethanol | 936211-30-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡唑并吡啶类
• 英文名称: 2-(3-aminopyrazolo[1,5-a]pyridin-2-yloxy)ethanol
• 英文别名: 2-(3-Aminopyrazolo[1,5-a]pyridin-2-yl)oxyethanol
• CAS: 936211-30-2
• 化学式: C₉H₁₁N₃O₂
• 分子量: 193.205
• InChiKey: VBZVYRJXFGQJTI-UHFFFAOYSA-N

物化性质

• 密度：
  1.41±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.22
• 拓扑面积：
  72.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-(3-aminopyrazolo[1,5-a]pyridin-2-yloxy)ethanol 在 5%-palladium/activated carbon 、 甲酸铵 、 N,N-二异丙基乙胺 作用下， 以 N-甲基吡咯烷酮 、 甲醇 、 乙醇 为溶剂， 反应 5.5h， 生成 2-{3-[2-amino-5-[4-(ethylisopropylamino)phenylamino]-4-iminocyclohexa-2,5-dienylideneamino]pyrazolo[1,5-a]pyridin-2-yloxy}ethanol
  参考文献：
  名称：

  [EN] (DIS)SYMMETRIC AZOMETHINE-TYPE DIRECT DYE COMPRISING AT LEAST ONE PYRAZOLOPYRIDINE UNIT, PROCESS FOR DYEING KERATIN FIBERS USING THIS DYE
  [FR] COLORANT DIRECT DE TYPE AZOMÉTHINE (DIS)SYMÉTRIQUE COMPRENANT AU MOINS UN MOTIF PYRAZOLOPYRIDINE, PROCÉDÉ DE COLORATION DE FIBRES KÉRATINIQUES À L'AIDE DE CE COLORANT

  摘要：

  本发明的主题是包括至少一个式(I)的吡唑吡啶单元的对称或非对称偶氮亚甲基直接染料，包括所述染料的组合物，使用所述染料处理角蛋白纤维的方法，制备这些化合物的方法，合成中间体和套件。其中式(I)中X、Y1、Y2、Z1和R1至R5如描述中所定义。

  公开号：

  WO2017220670A1

文献信息

• Composition for the dyeing of keratin fibers comprising at least one 3-amino-pyrazolopyridine derivatives
  申请人：Fadli Aziz

  公开号：US20070143935A1

  公开（公告）日：2007-06-28

  Disclosed herein is a composition for the dyeing of keratin fibers, for example, human keratin fibers such as the hair, comprising at least one 3-amino pyrazolo-[1,5-a]-pyridine derivative or one of its addition salts and a method employing this derivative. The composition of the present disclosure makes it possible to obtain coloration in various shades that is powerful, chromatic, and aesthetic, with low selectivity and with good resistance to various aggressive factors to which the hair may be subjected, such as shampoos, the light, sweat and permanent shaping.

  本公开涉及一种用于染色角蛋白纤维的组合物，例如，人类角蛋白纤维，如头发，包括至少一种3-氨基吡唑并[1,5-a]-吡啶衍生物或其加合盐以及采用该衍生物的方法。本公开的组合物使得可以获得各种色调的着色，具有强大、色彩丰富和美观的特性，具有低选择性，并且对头发可能受到的各种侵蚀因素具有良好的抵抗力，如洗发水、光线、汗水和永久造型。
• [EN] 4-AMINOINDOLE DERIVATIVES AND USE THEREOF FOR THE OXIDATION DYEING OF KERATIN FIBRES<br/>[FR] DÉRIVÉS DE 4-AMINOINDOLE ET LEUR UTILISATION POUR LA COLORATION D'OXYDATION DE FIBRES DE KÉRATINE
  申请人：OREAL

  公开号：WO2012080288A1

  公开（公告）日：2012-06-21

  The invention relates to 4-aminoindole derivatives of formula (I), and the addition salts thereof, mesomers thereof, isomers thereof and solvates thereof: and to their use for the oxidation dyeing of keratin fibres, and in particular of human keratin fibres such as the hair. The present invention makes it possible to achieve dark shades, natural shades and dark natural shades. The present invention also makes it possible to obtain powerful, chromatic, aesthetic, sparingly selective coloration of keratin fibres in varied shades, which is resistant to the various attacking factors to which the hair may be subjected. In particular, when the 4-aminoindole derivatives are combined with one or more heterocyclic oxidation bases, they make it possible to obtain a wide range of colours and coloration of keratin fibres that shows good chromaticity and good selectivity.

  本发明涉及式（I）的4-氨基吲哚衍生物及其加成盐、共轭体、异构体和溶剂化物，以及它们在角蛋白纤维的氧化染色中的应用，特别是在人类角蛋白纤维，如头发的染色中。本发明使得可以获得深色、自然色和深自然色。本发明还使得可以获得强有力的、色彩艳丽的、美学的、节约选择性的角蛋白纤维染色，其颜色多样，且对头发可能遭受的各种攻击因素具有抵抗力。特别地，当将4-氨基吲哚衍生物与一种或多种杂环氧化碱结合时，它们使得可以获得广泛的颜色范围和良好的色度和选择性的角蛋白纤维染色。
• [EN] KERATIN DYEING COMPOUNDS, COMPOSITIONS CONTAINING THEM, AND METHOD AND USE THEREOF<br/>[FR] COMPOSÉS POUR LA COLORATION DE LA KÉRATINE, COMPOSITIONS LES CONTENANT, ET LEUR PROCÉDÉ ET UTILISATION
  申请人：NOXELL CORP

  公开号：WO2019074736A1

  公开（公告）日：2019-04-18

  A novel class of 3-halo-1H-indol-4-amine derivatives, particularly for dyeing keratin fibers, the azomethine dyes formed from them, their uses as a coupler for dyeing keratin fibers, hair dyeing compositions comprising them, method of dyeing hair thereof, and a hair dyeing kit thereof are disclosed. The products of the oxidative coupling with hair dye primary intermediates, particularly pyrazole derivative, a p-phenylenediamine derivative, a p-aminophenol derivative, have improved fastness properties over currently used violet-blue to blue azomethine dyes.

  本发明揭示了一类新型的3-卤代-1H-吲哚-4-胺衍生物，特别用于染色角蛋白纤维，由它们形成的偶氮甲基染料，它们作为角蛋白纤维染料的偶合剂的用途，包括它们的头发染料组合物，染发方法以及染发套装。这些产品通过与头发染料原料，特别是吡唑衍生物、对苯二胺衍生物、对氨基苯酚衍生物的氧化偶联，具有比目前使用的紫蓝色到蓝色偶氮甲基染料更好的牢度性能。
• [EN] DYE COMPOSITION COMPRISING A CATIONIC META-PHENYLENEDIAMINE<br/>[FR] COMPOSITION DE COLORANT COMPRENANT UNE MÉTA-PHÉNYLÈNEDIAMINE CATIONIQUE
  申请人：OREAL

  公开号：WO2014005900A1

  公开（公告）日：2014-01-09

  One subject of the invention is a meia-phenylenediamine compound having formula (I) below, the addition salts thereof with an acid and the solvates thereof: in which: • R represents a hydrogen or halogen atom; a C1-C4 alkyl group; a carboxyl group or a (C1-C4)alkoxycarbonyl group, • R1 represents a C1-C10(hydroxy)alkyl group, optionally interrupted with one or more non-adjacent oxygen atoms or non-adjacent NR' substituents, substituted by a cationic CAT group, • R2 represents a hydrogen atom or a C1-C4(hydroxy)alkyl group, • R1 and R2 may form, together with the atom that bears them, a cationic heterocycle with 5 to 8 members, • R' represents a hydrogen atom or a C1-C4(hydroxy)alkyl group; • An" represents an anion or a mixture of anions which are organic or inorganic and cosmetically acceptable.

  本发明的一个主题是具有以下公式（I）的介苯二胺化合物及其与酸的加成盐和溶剂化物：其中： • R代表氢或卤素原子；C1-C4烷基；羧基或（C1-C4）烷氧羰基基团， • R1代表C1-C10（羟基）烷基，可选地中断一个或多个非相邻氧原子或非相邻NR'取代基，被带正电荷的CAT基团取代， • R2代表氢原子或C1-C4（羟基）烷基， • R1和R2可以与承载它们的原子一起形成具有5到8个成员的带正电荷的杂环， • R'代表氢原子或C1-C4（羟基）烷基； • An"代表有机或无机的、在化妆品中可接受的阴离子或阴离子混合物。
• COMPOSITION FOR THE DYEING OF KERATIN FIBERS COMPRISING AT LEAST ONE 3-AMINO-PYRAZOLOPYRIDINE DERIVATIVE
  申请人：Fadli Aziz

  公开号：US20100115711A1

  公开（公告）日：2010-05-13

  Disclosed herein is a composition for the dyeing of keratin fibers, for example, human keratin fibers such as the hair, comprising at least one 3-amino pyrazolo-[1,5-a]-pyridine derivative or one of its addition salts and a method employing this derivative. The composition of the present disclosure makes it possible to obtain coloration in various shades that is powerful, chromatic, and aesthetic, with low selectivity and with good resistance to various aggressive factors to which the hair may be subjected, such as shampoos, the light, sweat and permanent shaping.

  本文公开了一种用于染色角蛋白纤维（例如人类角蛋白纤维，如头发）的组合物，包括至少一种3-氨基吡唑并[1,5-a]-吡啶衍生物或其加合物盐以及采用该衍生物的方法。本公开的组合物使得能够获得各种强烈、色彩丰富、美观的染色效果，具有低选择性并对头发可能遭受的各种侵害因素具有良好的耐受性，例如洗发水、光线、汗水和永久造型。