((11S,14R,18R)-14-amino-18-dodecanamido-11-methyl-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontyl)phosphonic acid | 1337526-05-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ((11S,14R,18R)-14-amino-18-dodecanamido-11-methyl-13-oxo-3,6,9,20-tetraoxa-16-thia-12-azadotriacontyl)phosphonic acid
• 英文别名: 2-[2-[2-[(2S)-2-[[(2R)-2-amino-3-[(2R)-2-(dodecanoylamino)-3-dodecoxypropyl]sulfanylpropanoyl]amino]propoxy]ethoxy]ethoxy]ethylphosphonic acid
• CAS: 1337526-05-2
• 化学式: C₃₉H₈₀N₃O₉PS
• 分子量: 798.119
• InChiKey: CDWOUXRUPSRHPY-QOEXFKEZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.2
• 重原子数：
  53
• 可旋转键数：
  41
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.95
• 拓扑面积：
  204
• 氢给体数：
  5
• 氢受体数：
  11

文献信息

• Formulation of immunopotentiators
  申请人：Singh Manmohan

  公开号：US20120177681A1

  公开（公告）日：2012-07-12

  Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

  免疫增强剂可以被吸附到不溶性金属盐中，例如铝盐，以修改它们的药代动力学、药效学、肌肉内滞留时间和/或免疫刺激作用。免疫增强剂被改性以引入一个基团，例如膦酸盐基团，可以介导吸附。即使以吸附形式传递，这些改性化合物也可以保留或改善它们在体内的免疫活性。
• ADSORPTION OF IMMUNOPOTENTIATORS TO INSOLUBLE METAL SALTS
  申请人：Singh Manmohan

  公开号：US20130274465A1

  公开（公告）日：2013-10-17

  Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

  免疫增强剂可以吸附到不溶性金属盐上，例如铝盐，以改变它们的药代动力学、药效学、肌肉内滞留时间和/或免疫刺激作用。免疫增强剂被修改以引入一个基团，例如磷酸酯基团，可以介导吸附。即使以吸附形式输送，这些修改的化合物仍然可以保持或改善它们的体内免疫活性。
• COMPOUNDS (CYSTEIN BASED LIPOPEPTIDES) AND COMPOSITIONS AS TLR2 AGONISTS USED FOR TREATING INFECTIONS, INFLAMMATIONS, RESPIRATORY DISEASES ETC.
  申请人：Wu Tom Yao-Hsiang

  公开号：US20130065861A1

  公开（公告）日：2013-03-14

  The invention provides a novel class of compounds viz. generally lipopeptides like Pam3CSK4, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness a vaccine.

  该发明提供了一类新型化合物，即通常为脂肽类似物Pam3CSK4的脂肽类化合物，以及包含这些化合物的免疫原组合物和药物组合物，以及使用这些化合物治疗或预防与Toll样受体2相关的疾病或紊乱的方法。在一个方面，这些化合物可用作增强疫苗有效性的佐剂。
• COMPOUNDS AND COMPOSITIONS AS TLR2 AGONISTS
  申请人：WU Tom Yao-Hsiang

  公开号：US20140323390A1

  公开（公告）日：2014-10-30

  The invention provides a novel class of compounds, immunogenic compositions and pharmaceutical compositions comprising such compounds and methods of using such compounds to treat or prevent diseases or disorders associated with Toll-Like Receptors 2. In one aspect, the compounds are useful as adjuvants for enhancing the effectiveness of a vaccine.

  本发明提供了一种新的化合物类别，免疫原组合物和包含这种化合物的药物组合物，以及使用这种化合物来治疗或预防与Toll样受体2相关的疾病或障碍的方法。在一个方面，这些化合物可用作佐剂，以增强疫苗的有效性。
• Adsorption of immunopotentiators to insoluble metal salts
  申请人：Novartis AG

  公开号：EP2719395A1

  公开（公告）日：2014-04-16

  Immunopotentiators can be adsorbed to insoluble metal salts, such as aluminium salts, to modify their pharmacokinetics, pharmacodynamics, intramuscular retention time, and/or immunostimulatory effect. Immunopotentiators are modified to introduce a moiety, such as a phosphonate group, which can mediate adsorption. These modified compounds can retain or improve their in vivo immunological activity even when delivered in an adsorbed form.

  免疫促效剂可吸附在铝盐等不溶性金属盐上，以改变其药代动力学、药效学、肌内滞留时间和/或免疫刺激效果。对免疫增强剂进行改性，引入一个可介导吸附的分子（如膦酸基）。这些经过修饰的化合物即使以吸附形式给药，也能保持或提高其体内免疫活性。