tert-butyl ((3R,4R,5S)-1-(3-aminopyridin-4-yl)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-3-yl)carbamate | 1210418-70-4

分子结构分类

有机化合物 - 有机氮化合物

中文名称

——

中文别名

——

英文名称

tert-butyl ((3R,4R,5S)-1-(3-aminopyridin-4-yl)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-3-yl)carbamate

英文别名

tert-butyl ((3R,4R,5S)-1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)-5-methylpiperidin-3-yl)carbamate；tert-butyl (3R,4R,5S)-1-(3-aminopyridin-4-yl)-4-(tert-butyldimethylsilyloxy)-5-methylpiperidin-3-ylcarbamate；tert-butyl ((3R,4R,5S)-1-(3-amino-4-pyridinyl)-4-((tert-butyl(dimethyl)silyl)oxy)-5-methyl-3-piperidinyl)carbamate；tert-butyl N-[(3R,4R,5S)-1-(3-aminopyridin-4-yl)-4-[tert-butyl(dimethyl)silyl]oxy-5-methylpiperidin-3-yl]carbamate

tert-butyl ((3R,4R,5S)-1-(3-aminopyridin-4-yl)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-3-yl)carbamate化学式

CAS

1210418-70-4

化学式

C₂₂H₄₀N₄O₃Si

mdl

——

分子量

436.67

InChiKey

GSWPSACSLTUZMB-KVSKMBFKSA-N

BEILSTEIN

——

EINECS

——

物化性质

沸点：

536.1±50.0 °C(Predicted)
密度：

1.07±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(Predicted)

计算性质

辛醇/水分配系数(LogP)：

4.4
重原子数：

30
可旋转键数：

7
环数：

2.0
sp3杂化的碳原子比例：

0.73
拓扑面积：

89.7
氢给体数：

2
氢受体数：

6

上下游信息

上游原料

中文名称	英文名称	CAS号	化学式	分子量
——	tert-butyl [(3R,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methyl-1-(3-nitropyridin-4-yl)piperidin-3-yl]carbamate	1210418-69-1	C₂₂H₃₈N₄O₅Si	466.653
——	tert-butyl ((3R,4R,5S)-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-3-yl)carbamate	1210418-68-0	C₁₇H₃₆N₂O₃Si	344.57
——	tert-butyl [(1R,2R,3S)-4-azido-2-{[tert-butyl(dimethyl)silyl]oxy}-1-(hydroxymethyl)-3-methylbutyl]carbamate	1210418-63-5	C₁₇H₃₆N₄O₄Si	388.583
——	(2R,3R,4S)-5-azido-2 [(tert-butoxycarbonyl)amino]-3-{[tert-butyl(dimethyl)silyl]oxy}-4-methylpentyl methanesulfonate	1210418-65-7	C₁₈H₃₈N₄O₆SSi	466.674

下游产品

中文名称	英文名称	CAS号	化学式	分子量
——	tert-butyl tert-butoxycarbonyl(4-((3R,4R,5S)-3-((tert-butoxycarbonyl)amino)-4-hydroxy-5-methylpiperidin-1-yl)pyridin-3-yl)carbamate	——	C₂₆H₄₂N₄O₇	522.642
——	tert-butyl ((3R,4R,5S)-1-[3-({[3-amino-7-(1-methylpiperidin-4-yl)quinolin-2-yl]carbonyl}amino)pyridin-4-yl]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-3-yl)carbamate	1620240-50-7	C₃₈H₅₇N₇O₄Si	704.001
——	tert-butyl ((3R,4R,5S)-1-[3-({[3-amino-7-(tetrahydro-2H-pyran-4-yl)quinolin-2-yl]carbonyl}amino)pyridin-4-yl]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-3-yl)carbamate	1620240-47-2	C₃₇H₅₄N₆O₅Si	690.958
——	tert-butyl methyl [(3R,4S,5S)-1-(3-aminopyridin-4-yl)-5-methylpiperidine-3,4-diyl]biscarbamate	1620241-03-3	C₁₈H₂₉N₅O₄	379.459
——	(3R,4R,5S)-1-(3-(bis(tert-butoxycarbonyl)amino)pyridin-4-yl)-3-((tert-butoxycarbonyl)amino)-5-methylpiperidin-4-yl methanesulfonate	——	C₂₇H₄₄N₄O₉S	600.734
——	benzyl [7-bromo-2-({[4-((3R,4R,5S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-1-yl)pyridin-3-yl]amino}carbonyl)quinolin-3-yl]carbamate	1620240-45-0	C₄₀H₅₁BrN₆O₆Si	819.871
——	benzyl [2-({[4-((3R,4R,5S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-1-yl)pyridin-3-yl]amino}carbonyl)-7-(4-methylpiperazin-1-yl)quinolin-3-yl]carbamate	1620240-32-5	C₄₅H₆₂N₈O₆Si	839.123
——	benzyl [2-({[4-((3R,4R,5S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-1-yl)pyridin-3-yl]amino}carbonyl)-7-morpholin-4-ylquinolin-3-yl]carbamate	1620240-10-9	C₄₄H₅₉N₇O₇Si	826.081
——	tert-butyl ((3R,4S,5S)-1-(3-isothiocyanatopyridin-4-yl)-5-methyl-4-(N-methylacetamido)piperidin-3-yl)carbamate	1616587-19-9	C₂₀H₂₉N₅O₃S	419.548
——	benzyl [2-({[4-((3R,4R,5S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-1-yl)pyridin-3-yl]amino}carbonyl)-7-(3,6-dihydro-2H-pyran-4-yl)quinolin-3-yl]carbamate	1620240-46-1	C₄₅H₅₈N₆O₇Si	823.077
——	methyl ((3R,4S,5S)-3-((tert-butoxycarbonyl)amino)-1-(3-isothiocyanatopyridin-4-yl)-5-methylpiperidin-4-yl)(methyl)carbamate	1616587-18-8	C₂₀H₂₉N₅O₄S	435.547
——	benzyl [2-({[4-((3R,4R,5S)-3-[(tert-butoxycarbonyl)amino]-4-{[tert-butyl(dimethyl)silyl]oxy}-5-methylpiperidin-1-yl)pyridin-3-yl]amino}carbonyl)-7-(1-methyl-1,2,3,6-tetrahydropyridin-4-yl)quinolin-3-yl]carbamate	1620240-49-4	C₄₆H₆₁N₇O₆Si	836.119
——	di-tert-butyl (4-{(3R,4S,5S)-4-amino-3-[(tert-butoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)imidodicarbonate	1620241-01-1	C₂₆H₄₃N₅O₆	521.657
——	tert-butyl [(3R,4S,5S)-1-(3-aminopyridin-4-yl)-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-3-yl]carbamate	1620240-80-3	C₁₈H₂₇N₇O₂	373.458
——	di-tert-butyl (4-{(3R,4S,5S)-3-[(tert-butoxycarbonyl)amino]-4-[(methoxycarbonyl)amino]-5-methylpiperidin-1-yl}pyridin-3-yl)imidodicarbonate	1620241-02-2	C₂₈H₄₅N₅O₈	579.694
——	tert-butyl (4-((3R,4S,5S)-4-azido-3-((tert-butoxycarbonyl)amino)-5-methylpiperidin-1-yl)pyridin-3-yl)(tert-butoxycarbonyl)carbamate	——	C₂₆H₄₁N₇O₆	547.655
——	di-tert-butyl {4-[(3R,4S,5S)-3-[(tert-butoxycarbonyl)amino]-5-methyl-4-(1H-1,2,3-triazol-1-yl)piperidin-1-yl]pyridin-3-yl}imidodicarbonate	1620240-79-0	C₂₈H₄₃N₇O₆	573.693
——	tert-butyl tert-butoxycarbonyl(4-((3R,4S,5S)-3-((tert-butoxycarbonyl)amino)-4-(4-(hydroxymethyl)-1H-1,2,3-triazol-1-yl)-5-methylpiperidin-1-yl)pyridin-3-yl)carbamate	——	C₂₉H₄₅N₇O₇	603.719
——	tert-butyl methyl [(3R,4S,5S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-7-morpholin-4-ylquinolin-2-yl)carbonyl]amino}pyridin-4-yl)-5-methylpiperidine-3,4-diyl]biscarbamate	1620241-07-7	C₄₀H₄₈N₈O₈	768.87
——	tert-butyl methyl [(3R,4S,5S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-7-bromoquinolin-2-yl)carbonyl]amino}pyridin-4-yl)-5-methylpiperidine-3,4-diyl]biscarbamate	1620241-04-4	C₃₆H₄₀BrN₇O₇	762.66
——	tert-butyl methyl {(3R,4S,5S)-1-[3-({[3-{[(benzyloxy)carbonyl]amino}-7-(4-methylpiperazin-1-yl)quinolin-2-yl]carbonyl}amino)pyridin-4-yl]-5-methylpiperidine-3,4-diyl}biscarbamate	1620241-10-2	C₄₁H₅₁N₉O₇	781.912
——	tert-butyl methyl [(3R,4S,5S)-1-(3-{[(3-{[(benzyloxy)carbonyl]amino}-7-vinylquinolin-2-yl)carbonyl]amino}pyridin-4-yl)-5-methylpiperidine-3,4-diyl]biscarbamate	1620241-05-5	C₃₈H₄₃N₇O₇	709.802
——	3-amino-N-{4-[(3R,4R,5S)-3-amino-4-hydroxy-5-methylpiperidin-1-yl]pyridin-3-yl}-7-(4-methylpiperazin-1-yl)quinoline-2-carboxamide	1620240-31-4	C₂₆H₃₄N₈O₂	490.608