3(S)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone | 110410-94-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡喃
• 英文名称: 3(S)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone
• 英文别名: 3(S)-<1(R),4-Dimethyl-2(Z)-pentenyl>-4(S)-methyl-5(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone；3(S)-<1(R),4-Dimethyl-2(E)-pentenyl>-4(S)-methyl-5(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone；3(R)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone；3(S)-<1(S),4-dimethyl-2-(E)-pentenyl>-4(R)-methyl-5(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone；3(R)-<1(S),4-dimethyl-2-(E)-pentenyl>-4(R)-methyl-5-(S)-<1(R)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-dihydro-2(3H)-furanone；3(R)-(1(R),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone；3(R)-(1(R),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-{1(S)-methyl-2[(tert-butyldiphenylsilyl)oxy]ethyl}dihydro-2(3H)-furanone
• CAS: 110410-94-1；110455-56-6；115115-15-6；115115-16-7；115115-21-4；115115-22-5；126720-97-6；126720-98-7
• 化学式: C₃₁H₄₄O₃Si
• 分子量: 492.774
• InChiKey: JFEARGGKOPQNJS-JMPNCHQNSA-N

物化性质

• 沸点：
  548.2±32.0 °C(predicted)
• 密度：
  1.02±0.1 g/cm3(Temp: 20 °C; Press: 760 Torr)(predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  6.23
• 重原子数：
  35.0
• 可旋转键数：
  9.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.52
• 拓扑面积：
  35.53
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为产物：
  描述：

  4(S)-methyl-5(R)-<1(S)-methyl-2-<(tert-butyldiphenylsilyl)oxy>ethyl>-dihydro-2(3H)furanone 在 四(三苯基膦)钯 、 sodium hydride 、 三苯基膦 、 lithium chloride 、 lithium diisopropyl amide 作用下， 以 水 、 二甲基亚砜 为溶剂， 反应 9.0h， 生成 3(S)-(1(S),4-dimethyl-2(E)-pentenyl)-4(S)-methyl-5(R)-<1(S)-methyl-2<(tert-butyldiphenylsilyl)oxy>ethyl>dihydro-2(3H)-furanone
  参考文献：
  名称：

  Applications of the 3-methyl-.gamma.-butyrolactone strategy to the synthesis of polypropionates: the Prelog-Djerassi lactonic ester, ent-invictolide, and the C19-C27 fragment of rifamycin S

  摘要：

  DOI：

  10.1021/ja00224a032