DL-2-acetoxy-propionic acid dimethylamide | 6280-18-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: DL-2-acetoxy-propionic acid dimethylamide
• 英文别名: 2-acetoxy-propionic acid dimethylamide；DL-2-Acetoxy-propionsaeure-dimethylamid；O-Acetyl-DL-milchsaeure-dimethylamid；2-Acetoxy-propionsaeure-dimethylamid；1-(Dimethylamino)-1-oxopropan-2-yl acetate；[1-(dimethylamino)-1-oxopropan-2-yl] acetate
• CAS: 6280-18-8
• 化学式: C₇H₁₃NO₃
• 分子量: 159.185
• InChiKey: REUPEIPRASIZOF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  46.6
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  DL-2-acetoxy-propionic acid dimethylamide 生成 N,N-二甲基丙烯酰胺
  参考文献：
  名称：

  Ratchford; Fisher, Journal of the American Chemical Society, 1947, vol. 69, p. 1913

  摘要：

  DOI：
• 作为产物：
  描述：

  ()-(+)-2-乙酰氧基丙酰氯 、 二甲胺 在 乙醚 作用下， 生成 DL-2-acetoxy-propionic acid dimethylamide
  参考文献：
  名称：

  Freudenberg; Markert, Chemische Berichte, 1927, vol. 60, p. 2447

  摘要：

  DOI：

文献信息

• [EN] PROCESS FOR MANUFACTURING N,N-DIALKYL LACTAMIDE<br/>[FR] PROCÉDÉ POUR LA FABRICATION DE N,N-DIALKYLLACTAMIDE
  申请人：PURAC BIOCHEM BV

  公开号：WO2010037776A1

  公开（公告）日：2010-04-08

  The present invention pertains to a process for manufacturing dialkyl lactamide comprising the steps of reacting lactide and dialkylamine selected from one or more of dimethylamine, diethylamine, and methylethylamine to form a reaction mixture which comprises dialkyl lactamide selected from N, N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide, N,N-dialkyl lactoyl lactamide, and dialkylamine, subjecting the reaction mixture to a separation step to form a product stream comprising N,N-dialkyl lactamide, a first recycle stream comprising dialkylamine and a second recycle stream comprising N,N-dialkyl lactoyl lactamide, feeding the recycle streams to the reaction step, and isolating the product stream. The process allows the manufacture of N, N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide on commercial scale.

  本发明涉及一种制造二烷基内酰胺的方法，包括以下步骤：将内酯和二烷基胺（所选自二甲胺、二乙胺和甲乙胺）反应，形成反应混合物，其中包括所选自N，N-二甲基内酰胺、N，N-二乙基内酰胺、N，N-甲乙基内酰胺、N，N-二烷基内酰基内酰胺和二烷基胺的二烷基内酰胺；将反应混合物经过分离步骤，形成产品流，其中包括N，N-二烷基内酰胺、第一循环流，包括二烷基胺和第二循环流，包括N，N-二烷基内酰基内酰胺；将循环流送回反应步骤，隔离产品流。该方法允许商业化生产N，N-二甲基内酰胺、N，N-二乙基内酰胺和N，N-甲乙基内酰胺。
• PROCESS FOR MANUFACTURING N,N-DIALKYL LACTAMIDE
  申请人：PURAC Biochem BV

  公开号：EP2346812A1

  公开（公告）日：2011-07-27
• PROCESS FOR MANUFACTURING N, N-DIALKYL LACTAMIDE
  申请人：Van Krieken Jan

  公开号：US20110178339A1

  公开（公告）日：2011-07-21

  A process for manufacturing dialkyl lactamide including reacting lactide and dialkylamine selected from one or more of dimethylamine, diethylamine, and methylethylamine to form a reaction mixture which includes dialkyl lactamide selected from N,N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide, N,N-dialkyl lactoyl lactamide, and dialkylamine, subjecting the reaction mixture to a separation step to form a product stream including N,N-dialkyl lactamide, a first recycle stream including dialkylamine and a second recycle stream including N,N-dialkyl lactoyl lactamide, feeding the recycle streams to the reaction step, and isolating the product stream. The process allows the manufacture of N,N-dimethyl lactamide, N,N-diethyl lactamide, and N,N-methylethyl lactamide on a commercial scale.
• US8440860B2
  申请人：——

  公开号：US8440860B2

  公开（公告）日：2013-05-14