1-methyl-3-(naphthalen-1-yl)-5-(piperidin-1-ylmethyl)imidazolidine-2,4-dione | 1426236-29-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: 1-methyl-3-(naphthalen-1-yl)-5-(piperidin-1-ylmethyl)imidazolidine-2,4-dione
• 英文别名: 1-Methyl-3-naphthalen-1-yl-5-(piperidin-1-ylmethyl)imidazolidine-2,4-dione
• CAS: 1426236-29-4
• 化学式: C₂₀H₂₃N₃O₂
• 分子量: 337.422
• InChiKey: XIUXBMZWTIQBEG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  25
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  43.9
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-(methylamino)-3-(piperidin-1-yl)propanoic acid 在 盐酸 、 三乙胺 作用下， 以 二氯甲烷 为溶剂， 反应 73.0h， 生成 1-methyl-3-(naphthalen-1-yl)-5-(piperidin-1-ylmethyl)imidazolidine-2,4-dione
  参考文献：
  名称：

  Synthesis of Some New 5-Dialkylaminomethylhydantoins and Related Compounds

  摘要：

  In this paper, we describe the synthesis of new 5-dialkylaminomethyl-substituted hydantoin derivatives (3 and 9) from beta-aminoalanines (1 or 6) and some chemical properties of the synthesized compounds. A synthetic trial for the preparation of a new twin-drug type molecule (12) is also described.

  DOI：

  10.3987/com-12-12592

文献信息

• Antibacterial Activity of Some 5-Dialkylaminomethylhydantoins and Related Derivatives
  作者：Fumiko Fujisaki、Keiko Toyofuku、Mayu Egami、Shiori Ishida、Naho Nakamoto、Nobuhiro Kashige、Fumio Miake、Kunihiro Sumoto

  DOI：10.1248/cpb.c13-00461

  日期：——

  5-dialkylaminomethylhydantoins against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) strains, some molecular modifications were attempted. The antibacterial activities of all of the synthesized hydantoin derivatives were evaluated. Among the hydantoin derivatives designed in this study, C₂-symmetrical twin-drug type compound (7) showed the highest level of antibacterial activity

  与我们对5-二烷基氨基甲基乙内酰脲类抗革兰氏阴性（大肠埃希氏菌）和革兰氏阳性（金黄色葡萄球菌）菌株的抗菌化合物的研究有关，尝试了一些分子修饰。评价了所有合成的乙内酰脲衍生物的抗菌活性。在这项研究设计的乙内酰脲衍生物中，C 2-对称双药型化合物（7）对金黄色葡萄球菌菌株显示出最高水平的抗菌活性。