furan-2-carboxylic acid 2-[4-(2-oxo-2,3-dihydro-benzoimidazol-2-yl)-piperidin-1-yl]-ethylamide | 63004-86-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• 英文名称: furan-2-carboxylic acid 2-[4-(2-oxo-2,3-dihydro-benzoimidazol-2-yl)-piperidin-1-yl]-ethylamide
• 英文别名: N-(2-(4-(2-Oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)piperidin-1-yl)ethyl)furan-2-carboxamide；N-[2-[4-(2-oxo-3H-benzimidazol-1-yl)piperidin-1-yl]ethyl]furan-2-carboxamide
• CAS: 63004-86-4
• 化学式: C₁₉H₂₂N₄O₃
• 分子量: 354.409
• InChiKey: VINUTNSITPWXDD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  26
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.37
• 拓扑面积：
  77.8
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-(2-chloroethyl)furan-2-carboxamide 、 4-（2-酮酸-1-苯并咪唑）哌啶 、 碘化钾 在 4-甲基-2-戊酮 、 水 、 丙酮 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 19.0h， 以yielding a first fraction of 1 part of N-{2-[4-(2,3-dihydro-2-oxo-1H-benzimidazol-1-yl)-1-piperidinyl]ethyl}-2-furancarboxamide的产率得到furan-2-carboxylic acid 2-[4-(2-oxo-2,3-dihydro-benzoimidazol-2-yl)-piperidin-1-yl]-ethylamide
  参考文献：
  名称：

  N-[(1-piperidinyl)alkyl]arylcarboxamide derivatives

  摘要：

  这是一种N-[(1-哌啶基)烷基]芳基羧酰胺类化合物，可用作抗恶心和精神药物。

  公开号：

  US04031226A1

文献信息

• METHODS AND COMPOSITIONS OF TREATING HIV INFECTION
  申请人：Vanderbilt University

  公开号：US20140163055A1

  公开（公告）日：2014-06-12

  Disclosed are methods of treating HIV infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• METHODS AND COMPOSITIONS COMPRISING AKT INHIBITORS AND/OR PHOSPHOLIPASE D INHIBITORS
  申请人：Vanderbilt University

  公开号：US20140378524A1

  公开（公告）日：2014-12-25

  Disclosed are methods of treating viral infections or disorders of uncontrolled proliferation comprising, in one aspect, administering compounds that are phospholipase D inhibitors and/or Akt therapeutic agents. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• ANTIVIRAL THERAPIES WITH PHOSPHOLIPASE D INHIBITORS
  申请人：Lindsley Craig W.

  公开号：US20150025041A1

  公开（公告）日：2015-01-22

  Disclosed are methods of treating viral infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention. In accordance with the purpose(s) of the invention, as embodied and broadly described herein, the invention, in one aspect, relates to antiviral therapies. For example, compounds having Phospholipase D activity (e.g., isoform selective Phospholipase D inhibitors) can be useful in antiviral therapies (e.g., influenza treatments).
• Methods and Compositions for Treating HIV Infection
  申请人：Vanderbilt University

  公开号：US20160296506A1

  公开（公告）日：2016-10-13

  Disclosed are methods of treating HIV infections comprising, in one aspect, administering compounds that are phospholipase D inhibitors. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.
• US4031226A
  申请人：——

  公开号：US4031226A

  公开（公告）日：1977-06-21