5-bromo-6-chloro-N,N-diethylpyridine-3-sulfonamide | 622815-46-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 5-bromo-6-chloro-N,N-diethylpyridine-3-sulfonamide
• CAS: 622815-46-7
• 化学式: C₉H₁₂BrClN₂O₂S
• 分子量: 327.629
• InChiKey: OVBHASVDQJKCSZ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  58.6
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  5-bromo-6-chloro-N,N-diethylpyridine-3-sulfonamide 在 三乙胺 作用下， 以 乙醇 、 二氯甲烷 为溶剂， 反应 0.17h， 生成 4-(3-bromo-5-(N,N-diethylsulfamoyl)pyridin-2-yl)-N-phenylpiperazine-1-carboxamide
  参考文献：
  名称：

  A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor

  摘要：

  A novel series of P2Y(12) antagonists for development of drugs within the antiplatelet area is presented. The synthesis of the piperazinyl-pyridine urea derivatives and their structure-activity relationships (SAR) are described. Several compounds showed P2Y(12) antagonistic activities in the sub-micromolar range. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.088
• 作为产物：
  描述：

  3-溴-2-氯吡啶-5-磺酰氯 、 二乙胺 在 三乙胺 作用下， 以 四氢呋喃 为溶剂， 反应 2.5h， 生成 5-bromo-6-chloro-N,N-diethylpyridine-3-sulfonamide
  参考文献：
  名称：

  A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor

  摘要：

  A novel series of P2Y(12) antagonists for development of drugs within the antiplatelet area is presented. The synthesis of the piperazinyl-pyridine urea derivatives and their structure-activity relationships (SAR) are described. Several compounds showed P2Y(12) antagonistic activities in the sub-micromolar range. (C) 2011 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2011.03.088

文献信息

• [EN] NOVEL SULFONAMIDES AND THEIR USE AS NEUROPROTECTIVE AND/OR NEURORESTORATIVE AGENTS<br/>[FR] NOUVEAUX SULFONAMIDES ET LEUR UTILISATION EN TANT QU'AGENTS NEUROPROTECTEURS ET/OU NEURORESTORATEURS
  申请人：[en]GENECODE

  公开号：WO2024023284A1

  公开（公告）日：2024-02-01

  The present invention relates to a compound of general formula (I) or a pharmaceutically acceptable salt and/or solvate thereof. The invention further relates to the use of the compounds of the invention as neuroprotective and/or neurorestorative agents, in particular for use in the treatment of neurological disorders.