H-Tyr-Gly-Gly-Phe-Gly-OMe | 501082-86-6

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Tyr-Gly-Gly-Phe-Gly-OMe
• 英文别名: methyl 2-[[(2S)-2-[[2-[[2-[[(2S)-2-amino-3-(4-hydroxyphenyl)propanoyl]amino]acetyl]amino]acetyl]amino]-3-phenylpropanoyl]amino]acetate
• CAS: 501082-86-6
• 化学式: C₂₅H₃₁N₅O₇
• 分子量: 513.55
• InChiKey: ZZWIDOKPYRKASB-PMACEKPBSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  37
• 可旋转键数：
  14
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  189
• 氢给体数：
  6
• 氢受体数：
  8

反应信息

• 作为反应物：
  描述：

  H-Tyr-Gly-Gly-Phe-Gly-OMe 在 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 5.0h， 以89%的产率得到H-Tyr-Gly-Gly-Phe-Gly-OH
  参考文献：
  名称：

  Studies on the Synthesis of Estrogen-GHRPS Linkers

  摘要：

  A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxylmethyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Deb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H-2, and 4.4% formic acid in methanol.

  DOI：

  10.1081/scc-120018924
• 作为产物：
  描述：

  Boc-Tyr(2,6-Cl2Bzl)-Gly-Gly-Phe-OMe 在 palladium on activated charcoal sodium hydroxide 、 甲酸 、 氢气 、 1-羟基苯并三唑 、 N,N'-二环己基碳二亚胺 作用下， 以 甲醇 、 水 为溶剂， 反应 24.0h， 生成 H-Tyr-Gly-Gly-Phe-Gly-OMe
  参考文献：
  名称：

  Studies on the Synthesis of Estrogen-GHRPS Linkers

  摘要：

  A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxylmethyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Deb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H-2, and 4.4% formic acid in methanol.

  DOI：

  10.1081/scc-120018924

文献信息

• Studies on the Synthesis of Estrogen-GHRPS Linkers
  作者：Chao Wang、Ming Zhao、Weina Cui、Jian Yang、Shiqi Peng

  DOI：10.1081/scc-120018924

  日期：2003.1.6

  A series of linkers consisted of estrone, estradiol, and GHRPS (growth hormone releasing peptides) were prepared with carboxylmethyl or succinyl as the conjugated group. As a protective group in the side chain of Tyr, the Deb (2,6-dichlorobenzyl) in the intermediates which is unstable to HF can be removed in high yield in the presence of Pd/C (10%), H-2, and 4.4% formic acid in methanol.