1,2-二乙氧基-4-氯-苯 | 100703-98-8

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 中文名称: 1,2-二乙氧基-4-氯-苯
• 英文名称: 1,2-diethoxy-4-chloro-benzene
• 英文别名: 1,2-Diaethoxy-4-chlor-benzol；1-chloro-3,4-diethoxybenzene；Benzene, 4-chloro-1,2-diethoxy-；4-chloro-1,2-diethoxybenzene
• CAS: 100703-98-8
• 化学式: C₁₀H₁₃ClO₂
• 分子量: 200.665
• InChiKey: PXSQLCDCSVUESB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  13
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  18.5
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,2-二乙氧基-4-氯-苯 在 盐酸 、 三氯化铝 、 甲酸 作用下， 以 二氯甲烷 为溶剂， 反应 10.0h， 生成 1-(2-chloro-4,5-diethoxyphenyl)ethylamine
  参考文献：
  名称：

  Synthesis and anti-inflammatory activity of 1-acylaminoalkyl-3,4-dialkoxybenzene derivatives

  摘要：

  New 1-acylaminoalkyl-3,4-dialkoxybenzene derivatives 17-31 were synthesized by the acylation of amines 9-16 with acyl chlorides. Amines 9-16 were obtained from aryl ketones 1-8. Aryl ketones 1-8 were synthesized by the acylation of corresponding aromatic compounds. As it was preliminary predicted by PASS (Prediction of Activity Spectra for Substance) program, all 1-acylaminoalkyl-3,4-dimethoxy- and 3,4-diethoxybenzene derivatives possess anti-inflammatory activity. Activity of compounds 18, 19, 21, 24, 26, 27, 28, 29 was similar to that of acetylsalicylic acid or ibuprofen however their acute toxicity was less than that of mentioned anti-inflammatory drugs. A series of 1-acylaminoalkyl-3,4-dimethoxybenzene, 1-acylaminoalkyl-3,4-diethoxybenzene and 6-acylaminoalkyl-2,3-dihydro-1,4-benzodioxine derivatives have been synthesized. These compounds possess moderate or strong anti-inflammatory activity and low toxicity.

  DOI：

  10.1016/j.farmac.2004.12.003
• 作为产物：
  描述：

  邻苯二乙醚 在 磺酰氯 、 乙醚 作用下， 生成 1,2-二乙氧基-4-氯-苯
  参考文献：
  名称：

  Quelet; Ezz, Bulletin de la Societe Chimique de France, 1959, p. 349,351

  摘要：

  DOI：

文献信息

• METHOD FOR PRODUCING BIARYL COMPOUND
  申请人：Sato Koichi

  公开号：US20100087680A1

  公开（公告）日：2010-04-08

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种制备双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱的存在下，将芳香有机化合物与选自芳香基有机硼化合物和硼氧化物化合物组的至少一种化合物反应。
• PROCESS FOR PRODUCING BIARYL COMPOUND
  申请人：Sumitomo Chemical Company, Limited

  公开号：EP1914221A1

  公开（公告）日：2008-04-23

  A method for producing a biaryl compound, comprising reacting an aromatic organic compound with at least one compound selected from the group consisting of aromatic organoboron compounds and boroxine compounds, in the presence of a zero-valent nickel catalyst, phosphine ligand and base.

  一种生产双芳基化合物的方法，包括在零价镍催化剂、膦配体和碱存在下，使芳香族有机化合物与至少一种选自由芳香族有机硼化合物和硼氧化合物组成的组中的化合物反应。
• PROCESS FOR PRODUCING PROPYLENE BLOCK COPOLYMER
  申请人：FUJIWARA Yasuki

  公开号：US20100004395A1

  公开（公告）日：2010-01-07

  A production process of a propylene block copolymer, comprising the step (I) of polymerizing propylene alone or a combination of propylene with an olefin other than propylene, in the presence of a defined polymerization catalyst, to form a polymer component (1), and the step (II) of copolymerizing propylene with an olefin other than propylene in the presence of the polymer component (1), to form a polymer component (2), wherein a combination of a transition metal compound such as Zr(OR 1 ) 4 and Hf(OR 1 ) 4 (R 1 being a hydrocarbon group) with an ether group-containing linear hydrocarbon compound and/or a Lewis base compound is added to the above polymerization system between the ending point of the step (I) and the starting point of the step (II), or during the step (II).
• US8039552B2
  申请人：——

  公开号：US8039552B2

  公开（公告）日：2011-10-18