tert-butyl N-<16-azido-13-(trifluoroacetyl)-4-<2-(trimethylsilyl)ethylsulfonyl>-4,9,13-triazahexadecyl>carbamate | 220095-17-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 有机磺酸及其衍生物
• 英文名称: tert-butyl N-<16-azido-13-(trifluoroacetyl)-4-<2-(trimethylsilyl)ethylsulfonyl>-4,9,13-triazahexadecyl>carbamate
• 英文别名: tert-butyl N-[3-[4-[3-[3-azidopropyl-(2,2,2-trifluoroacetyl)amino]propylamino]butyl-(2-trimethylsilylethylsulfonyl)amino]propyl]carbamate
• CAS: 220095-17-0
• 化学式: C₂₅H₅₀F₃N₇O₅SSi
• 分子量: 645.863
• InChiKey: WXGXQYNURAGMEY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.72
• 重原子数：
  42
• 可旋转键数：
  23
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  131
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为反应物：
  描述：

  (2E)-3-(4-甲氧基苯基)丙烯酰氯 、 tert-butyl N-<16-azido-13-(trifluoroacetyl)-4-<2-(trimethylsilyl)ethylsulfonyl>-4,9,13-triazahexadecyl>carbamate 在 三乙胺 作用下， 以 乙酸乙酯 为溶剂， 以92%的产率得到tert-butyl N-<16-azido-9-<3-(4-methoxyphenyl)prop-2-enoyl>-13-(trifluoroacetyl)-4-<2-(trimethylsilyl)ethylsulfonyl>-4,9,13-triazahexadecyl>carbamate
  参考文献：
  名称：

  Regioselective Deprotection and Acylation of Penta-N-Protected Thermopentamine

  摘要：

  The synthesis of the penta-N-protected polyamide 1 (ten-butyl N-{9-allyl-16-azido-13-(trinuoroacetyl)-4-[2-(trimethylsilyl)ethylsulfonyl]-4,9,13-triazahexadecyl]carbamate = tert-butyl N-{3-{[4-{allyl[3-[(3-azidopropyl)(trifluoroacetyl)aminopropyl}amino}butyl}{[2-(trimethylsilyl)ethyl]sulfonyl}amino}propyl}carbamate) is described, a derivative of thermopentamine (PA 3433) containing five independently removable amino-protecting groups. The selective deprotection of the five protecting groups used, it., of allyl, azido, (tert-butoxy)carbonyl (Boc). trifluoroacetyl, and [2-(trimethylsilyl)ethyl]sulfonyl (SES), as well as the rapid transamidation reaction of the trifluoroacetyl group yielding secondary amides is discussed. Subsequent acylation with 4-methoxycinnamoyl chloride at each N-atom of the pentamine backbone is achieved. For the acylation of the terminal N-atom the azido group is replaced by a (2,2,2-trichloro-1,l-dimethylethoxy)carbonyl (Tcboc) group.

  DOI：

  10.1002/(sici)1522-2675(19981216)81:12<2300::aid-hlca2300>3.0.co;2-7
• 作为产物：
  描述：

  N-(3-azidopropyl)-3-aminopropan-1-ol 在 4-二甲氨基吡啶 、 ammonium hydroxide 、 四(三苯基膦)钯 、 1,3-二甲基巴比妥酸 、 三乙胺 、 N,N-二异丙基乙胺 、 sodium iodide 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 反应 96.75h， 生成 tert-butyl N-<16-azido-13-(trifluoroacetyl)-4-<2-(trimethylsilyl)ethylsulfonyl>-4,9,13-triazahexadecyl>carbamate
  参考文献：
  名称：

  Regioselective Deprotection and Acylation of Penta-N-Protected Thermopentamine

  摘要：

  The synthesis of the penta-N-protected polyamide 1 (ten-butyl N-{9-allyl-16-azido-13-(trinuoroacetyl)-4-[2-(trimethylsilyl)ethylsulfonyl]-4,9,13-triazahexadecyl]carbamate = tert-butyl N-{3-{[4-{allyl[3-[(3-azidopropyl)(trifluoroacetyl)aminopropyl}amino}butyl}{[2-(trimethylsilyl)ethyl]sulfonyl}amino}propyl}carbamate) is described, a derivative of thermopentamine (PA 3433) containing five independently removable amino-protecting groups. The selective deprotection of the five protecting groups used, it., of allyl, azido, (tert-butoxy)carbonyl (Boc). trifluoroacetyl, and [2-(trimethylsilyl)ethyl]sulfonyl (SES), as well as the rapid transamidation reaction of the trifluoroacetyl group yielding secondary amides is discussed. Subsequent acylation with 4-methoxycinnamoyl chloride at each N-atom of the pentamine backbone is achieved. For the acylation of the terminal N-atom the azido group is replaced by a (2,2,2-trichloro-1,l-dimethylethoxy)carbonyl (Tcboc) group.

  DOI：

  10.1002/(sici)1522-2675(19981216)81:12<2300::aid-hlca2300>3.0.co;2-7