Z-Asn-Gly | 56675-97-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Z-Asn-Gly
• 英文别名: N-(N²-benzyloxycarbonyl-L-asparaginyl)-glycine；N-(N²-Benzyloxycarbonyl-L-asparaginyl)-glycin；Z-Asn-Gly-OH；2-[[(2S)-4-amino-4-oxo-2-(phenylmethoxycarbonylamino)butanoyl]amino]acetic acid
• CAS: 56675-97-9
• 化学式: C₁₄H₁₇N₃O₆
• 分子量: 323.305
• InChiKey: AIVHZBIRKPAQGR-JTQLQIEISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  23
• 可旋转键数：
  9
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  148
• 氢给体数：
  4
• 氢受体数：
  6

反应信息

• 作为反应物：
  描述：

  Z-Asn-Gly 生成 L-asparaginylglycine
  参考文献：
  名称：

  Leach; Lindley, Australian Journal of Chemistry, 1954, vol. 7, p. 173,178

  摘要：

  DOI：
• 作为产物：
  描述：

  N-(N-benzyloxycarbonyl-L-α-aspartyl)-glycine ethyl ester 在 sodium hydroxide 、 五氯化磷 作用下， 生成 Z-Asn-Gly
  参考文献：
  名称：

  Leach; Lindley, Australian Journal of Chemistry, 1954, vol. 7, p. 173,178

  摘要：

  DOI：

文献信息

• A One-Pot Peptide Synthesis via<u>Se</u>-phenyl Carboselenoate in Mixed Aqueous/Organic Solvent System
  作者：Sunil Kumar Ghosh、Usha Singh、Mohindra S. Chadha、Vasant R. Mamdapur

  DOI：10.1246/bcsj.66.1566

  日期：1993.5

  A one pot synthesis of peptides with free C-terminal residues has been accomplished via the active Se-phenyl carboselenoate using diphenyl diselenide, tributylphosphine, and N-methylmorpholine N-oxide in an acetonitrile– water mixed solvent system. Free amino acids and peptides have been used as the amine component without pH adjustment.

  通过活性硒代苯基羧硒酸酯，利用二苯基二硒化物、三丁基膦和N-甲基吗啉N-氧化物在丙酮腈-水混合溶剂体系中，实现了具有自由C端残基的多肽的一锅法合成。无需pH调节，自由氨基酸和多肽被用作氨基组分。
• Synthesis of peptides related to corticotropin (ACTH). IX. Application of N-hydroxy-5-norbornene-2,3-dicarboximide active ester procedure to the synthesis of human adrenocorticotropic hormone (.ALPHA.h-ACTH).
  作者：OSAMU NISHIMURA、CHITOSHI HATANAKA、MASAHIKO FUJINO

  DOI：10.1248/cpb.23.1212

  日期：——

  Human adrenocorticotropic hormone (αh-ACTH), H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH, was synthesized by using N-hydroxy-5-norbornene-2, 3-dicarboximide (HONB) with N, N'-dicyelohexylcarbodiimide (DCC) for the stepwise elongation and fragment condensation. The synthetic αh-ACTH, purified on a column of carboxymethylcellulose, Amberlite XAD-2 resin and Bio-Gel P-6, was found to be homogeneous by various criteria and exhibits full biological activity (ca. 145 units/mg) in in vitro steroidogenic assay.

  人促肾上腺皮质激素 (αh-ACTH)，H-Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val -Lys-Val-Tyr-Pro-Asn-Gly-Ala-Glu-Asp-Glu-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe-OH，使用N-羟基-5合成-降冰片烯-2, 3-二甲酰亚胺 (HONB) 与 N,N'-二环己基碳二亚胺 (DCC) 进行逐步延伸和片段缩合。合成的 αh-ACTH 在羧甲基纤维素、Amberlite XAD-2 树脂和 Bio-Gel P-6 柱上纯化，根据各种标准发现是均质的，并且在体外表现出完整的生物活性（约 145 单位/毫克）类固醇生成测定。
• Process for the preparation of biologically active polypeptides
  申请人：Richter Gedeon Vegyeszeti Gyar Rt

  公开号：US03953415A1

  公开（公告）日：1976-04-27

  The invention relates to the preparation of biologically active polypeptides containing the aspartyl group, particularly an aspartyl-glycine moiety, using the active-ester technique. According to the method of the invention, human adrenocorticotropic hormone and its fragments characteristic to the individual species, as well as the blocked derivatives of such compounds are prepared by the pentafluorophenol method, i.e., the carboxy group of the acylating component is activated by converting it into pentafluorophenyl ester in the coupling reaction carried out with blocked peptides containing the aspartyl group or an aspartylglycine moiety. The acylation is carried out preferably using equimolar quantities of the respective reactants. The free peptides obtained after removing the blocking groups can be converted into their acid addition salts or pharmaceutically acceptable complexes or condensates. Human adrenocorticotropic hormone and its derivatives are valuable substances of therapeutical activity.

  本发明涉及利用活性酯技术制备含有天冬氨酸基团的生物活性多肽，特别是含有天冬氨酸-甘氨酸基团的多肽。根据本发明的方法，利用五氟苯酚法制备人类肾上腺皮质激素和其特征性物种的片段，以及这些化合物的阻断衍生物。即，在与含有天冬氨酸基团或天冬氨酸-甘氨酸基团的阻断肽进行偶联反应时，通过将酰化组分的羧基转化为五氟苯酰酯来激活酰化组分的羧基。最好使用相应反应物的等摩尔量进行酰化。去除阻断基后获得的自由肽可以转化为其酸加合盐或药理学可接受的复合物或缩合物。人类肾上腺皮质激素及其衍生物是具有治疗活性的有价值的物质。
• METHOD FOR PRODUCING PLANT PROTEIN CONCENTRATE
  申请人：Amano Enzyme Inc.

  公开号：EP4029947A1

  公开（公告）日：2022-07-20

  The present invention addresses the problem of providing a means for efficiently producing a plant protein concentrate to be utilized in foods, beverages, etc. The present invention also addresses the problem of raising the utility value of plant proteins and contributing to the improvement of quality in existing uses and the discovery of new uses by making it possible to produce a plant protein concentrate having improved physical properties (especially solubility). The yield of plant protein is improved by treating a plant protein raw material such as peas, soybeans, almonds, etc., with a protein deamidase.

  本发明要解决的问题是提供一种有效生产植物蛋白浓缩物的方法，以用于食品、饮料等。本发明还解决了提高植物蛋白实用价值的问题，通过生产物理性质（特别是溶解性）得到改善的植物蛋白浓缩物，有助于提高现有用途的质量和发现新用途。用蛋白脱氨酶处理豌豆、大豆、杏仁等植物蛋白原料，可提高植物蛋白的产量。
• Novel transglutaminase
  申请人：AJINOMOTO CO., INC.

  公开号：EP0379606B2

  公开（公告）日：1999-07-28