4-nitro-2-naphthylbenzoyl-leucine methyl ester | 180977-42-8

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-nitro-2-naphthylbenzoyl-leucine methyl ester
• CAS: 180977-42-8
• 化学式: C₂₄H₂₄N₂O₅
• 分子量: 420.465
• InChiKey: MMIYIUBQEMVEIE-QFIPXVFZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.73
• 重原子数：
  31.0
• 可旋转键数：
  7.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  98.54
• 氢给体数：
  1.0
• 氢受体数：
  5.0

反应信息

• 作为反应物：
  描述：

  4-nitro-2-naphthylbenzoyl-leucine methyl ester 在 氢气 、 sodium cyanoborohydride 作用下， 生成
  参考文献：
  名称：

  Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics

  摘要：

  In this paper we describe the synthesis of a family of CAAL peptidomimetics as GGTase-I inhibitors. These inhibitors lack the central dipeptide AA in the key CAAL carboxy terminal sequence of geranylgeranylated proteins and are more selective for GGTase-I over FTase. In whole cells, these compounds are very potent inhibitors of the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras. One derivative, GGTI-298, inhibited cell division by blocking cells in the G(1) phase of the cell cycle. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(97)10040-2
• 作为产物：
  描述：

  4-硝基-2-(1-萘基)苯甲酸甲酯 生成 4-nitro-2-naphthylbenzoyl-leucine methyl ester
  参考文献：
  名称：

  Selective inhibition of type-I geranylgeranyltransferase in vitro and in whole cells by CAAL peptidomimetics

  摘要：

  In this paper we describe the synthesis of a family of CAAL peptidomimetics as GGTase-I inhibitors. These inhibitors lack the central dipeptide AA in the key CAAL carboxy terminal sequence of geranylgeranylated proteins and are more selective for GGTase-I over FTase. In whole cells, these compounds are very potent inhibitors of the processing of the geranylgeranylated protein Rap1A without affecting the farnesylated protein H-Ras. One derivative, GGTI-298, inhibited cell division by blocking cells in the G(1) phase of the cell cycle. (C) 1998 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0968-0896(97)10040-2