5-hydroxy-3,4-dimethyl-5-phenyl-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one | 1574486-24-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: 5-hydroxy-3,4-dimethyl-5-phenyl-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
• 英文别名: 5-Hydroxy-3,4-dimethyl-5-phenyl-1-pyridin-2-ylpyrrol-2-one；5-hydroxy-3,4-dimethyl-5-phenyl-1-pyridin-2-ylpyrrol-2-one
• CAS: 1574486-24-0
• 化学式: C₁₇H₁₆N₂O₂
• 分子量: 280.326
• InChiKey: RSYQWYNCACFRNJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  21
• 可旋转键数：
  2
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.18
• 拓扑面积：
  53.4
• 氢给体数：
  1
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  3,4-dimethyl-N-(2-pyridyl)maleinimid 、 二苯锌 以 四氢呋喃 为溶剂， 反应 16.0h， 以91%的产率得到5-hydroxy-3,4-dimethyl-5-phenyl-1-(pyridin-2-yl)-1H-pyrrol-2(5H)-one
  参考文献：
  名称：

  Efficient access to 3-substituted-γ-hydroxylactams: the uncatalyzed addition of diorganozinc reagents to cyclic imides with heterocyclic substitution

  摘要：

  A range of 3-substituted-gamma-hydroxylactams have been prepared via the uncatalyzed addition of organo-zinc nucleophiles to cyclic imides. This reactivity is primarily limited to imides containing heterocyclic N-substitution, but proceeds efficiently with a variety of diorganozinc reagents, including those prepared and utilized without purification, as well as organozinc halides. It is hypothesized that the presence of a Lewis basic directing group is required for optimum reactivity. (C) 2014 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2014.01.130

文献信息

• Efficient access to 3-substituted-γ-hydroxylactams: the uncatalyzed addition of diorganozinc reagents to cyclic imides with heterocyclic substitution
  作者：Kimberly S. DeGlopper、Joseph M. Dennis、Jeffrey B. Johnson

  DOI：10.1016/j.tetlet.2014.01.130

  日期：2014.3

  A range of 3-substituted-gamma-hydroxylactams have been prepared via the uncatalyzed addition of organo-zinc nucleophiles to cyclic imides. This reactivity is primarily limited to imides containing heterocyclic N-substitution, but proceeds efficiently with a variety of diorganozinc reagents, including those prepared and utilized without purification, as well as organozinc halides. It is hypothesized that the presence of a Lewis basic directing group is required for optimum reactivity. (C) 2014 Elsevier Ltd. All rights reserved.