1-(4-Chloro-3-fluoropyridin-2-YL)ethanone | 1393572-94-5

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 1-(4-Chloro-3-fluoropyridin-2-YL)ethanone
• CAS: 1393572-94-5
• 化学式: C₇H₅ClFNO
• 分子量: 173.57
• InChiKey: NPIWWBQSXWWVQE-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.6
• 重原子数：
  11
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.14
• 拓扑面积：
  30
• 氢给体数：
  0
• 氢受体数：
  3

安全信息

• 危险性防范说明：
  P261,P280,P301+P312,P302+P352,P305+P351+P338
• 危险性描述：
  H302,H315,H319,H335

反应信息

• 作为反应物：
  描述：

  1-(4-Chloro-3-fluoropyridin-2-YL)ethanone 在 N-甲基咪唑 、 ammonium acetate 、 氨 、 potassium carbonate 、 N,N,N',N'-tetramethylchloroformamidinium hexafluorophosphate 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 、 乙腈 为溶剂， 反应 49.5h， 生成 N-[1-[4-chloro-3-(4-methylsulfanylpyrazol-1-yl)-2-pyridyl]ethyl]-3,5-bis(trifluoromethyl)benzamide
  参考文献：
  名称：

  HETEROARYL COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS

  摘要：

  The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

  公开号：

  WO2024132636A1
• 作为产物：
  描述：

  N-甲氧基-N-甲基乙酰胺 、 4-氯-3-氟吡啶 在 三乙烯二胺 、 正丁基锂 作用下， 以 甲基叔丁基醚 为溶剂， 以61%的产率得到1-(4-Chloro-3-fluoropyridin-2-YL)ethanone
  参考文献：
  名称：

  HETEROARYL COMPOUNDS FOR THE CONTROL OF INVERTEBRATE PESTS

  摘要：

  The invention relates to compounds of formula (I) wherein the variables have the meanings as defined in the specification, to compositions comprising them, to active compound combinations comprising them, and to their use for protecting growing plants and animals from attack or infestation by invertebrate pests, furthermore, to seed comprising such compounds.

  公开号：

  WO2024132636A1

文献信息

• SUBSTITUTED BENZOFURAN, BENZOPYRROLE, BENZOTHIOPHENE, AND STRUCTURALLY RELATED COMPLEMENT INHIBITORS
  申请人：BioCryst Pharmaceuticals, Inc.

  公开号：US20190345135A1

  公开（公告）日：2019-11-14

  Disclosed are compounds of formulae I and II, and pharmaceutically acceptable salts and prodrugs thereof, which are inhibitors of the complement system. Also provided are pharmaceutical compositions comprising such a compound, and methods of using the compounds and compositions in the treatment or prevention of a disease or condition characterized by aberrant complement system activity.