4-Chlor-3-<2-dimethylamino-ethyl>-indol | 91766-93-7

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 4-Chlor-3-<2-dimethylamino-ethyl>-indol
• 英文别名: [2-(4-chloro-indol-3-yl)-ethyl]-dimethyl-amine；3-(2-dimethylaminoethyl)-4-chloroindole；2-(4-chloro-1H-indol-3-yl)-N,N-dimethylethanamine
• CAS: 91766-93-7
• 化学式: C₁₂H₁₅ClN₂
• 分子量: 222.718
• InChiKey: JLGAFYIPWQMGPG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.1
• 重原子数：
  15
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.33
• 拓扑面积：
  19
• 氢给体数：
  1
• 氢受体数：
  1

文献信息

• Processes for the production of tryptamines
  申请人：New Atlas Biotechnologies LLC

  公开号：US11136293B2

  公开（公告）日：2021-10-05

  Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae, genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.

  本文公开了经基因改造可生物合成色胺和色胺衍生物的原核和真核微生物，包括大肠杆菌和酿酒葡萄球菌。本发明公开的微生物可被设计成含有质粒和稳定的基因整合，其中包含将蒽酸或吲哚转化为色胺的足够遗传信息。在全细胞生物催化剂中发酵生产取代的色胺可能有助于以具有成本效益的方式生产这些用于治疗的化合物。
• TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT1-LIKE RECEPTORS OR 5-HT2 RECEPTOR AGONISTES
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0593513B1

  公开（公告）日：1998-10-28
• TRYPTAMINE ANALOGUES, THEIR SYNTHESIS AND THEIR USE AS 5-HT 1 -LIKE OR 5-HT 2 RECEPTOR
  申请人：SMITHKLINE BEECHAM PLC

  公开号：EP0593513A1

  公开（公告）日：1994-04-27
• PROCESSES FOR THE PRODUCTION OF TRYPTAMINES
  申请人：New Atlas Biotechnologies LLC

  公开号：US20210108238A1

  公开（公告）日：2021-04-15

  Disclosed herein are prokaryotic and eukaryotic microbes, including E. coli and S. cerevisiae , genetically altered to biosynthesize tryptamine and tryptamine derivatives. The microbes of the disclosure may be engineered to contain plasmids and stable gene integrations containing sufficient genetic information for conversion of an anthranilate or an indole to a tryptamine. The fermentative production of substituted tryptamines in a whole-cell biocatalyst may be useful for cost effective production of these compounds for therapeutic use.
• US5571833A
  申请人：——

  公开号：US5571833A

  公开（公告）日：1996-11-05