4-乙酰氨基-3-羟基苯甲酸乙酯 | 1346604-18-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 中文名称: 4-乙酰氨基-3-羟基苯甲酸乙酯
• 中文别名: 奥司他韦杂质D
• 英文名称: Ethyl 4-acetamido-3-hydroxybenzoate
• 英文别名: ethyl 4-acetamido-3-hydroxybenzoate
• CAS: 1346604-18-9
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: UURVEOMRNSPVTI-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1
• 重原子数：
  16
• 可旋转键数：
  4
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  75.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  3-(pyridin-2-ylethynyl)aniline 、 4-乙酰氨基-3-羟基苯甲酸乙酯 在 三甲基铝 作用下， 以 二氯甲烷 、 甲苯 为溶剂， 以9.45 %的产率得到4-Acetamido-3-hydroxy-N-(3-(pyridin-2-ylethynyl)phenyl)benzamide
  参考文献：
  名称：

  SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS

  摘要：

  The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.

  公开号：

  US20230192733A1

文献信息

• SUBSTITUTED PHENYL ET458HYNYL PYRIDINE CARBOXAMIDES AS POTENT INHIBITORS OF SARS VIRUS
  申请人：Southern Research Institute

  公开号：US20230192733A1

  公开（公告）日：2023-06-22

  The present disclosure is concerned with substituted phenyl ethynyl pyridine carboxamide compounds, pharmaceutical compositions comprising the compounds, and methods of treating viral infections due to a Coronavirus such as, for example, Middle East respiratory syndrome coronavirus (MERS-CoV), severe acute respiratory syndrome coronavirus (SARS-CoV), and severe acute respiratory syndrome coronavirus disease 2019 (SARS-CoV-2), using the compounds. This abstract is intended as a scanning tool for purposes of searching in the particular art and is not intended to be limiting of the present invention.