2-((benzyloxy)(4-bromophenyl)methyl)-4,5-dimethylthiazole | 1233239-33-2

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: 2-((benzyloxy)(4-bromophenyl)methyl)-4,5-dimethylthiazole
• CAS: 1233239-33-2
• 化学式: C₁₉H₁₈BrNOS
• 分子量: 388.328
• InChiKey: LLKNFULJBYUTJS-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.83
• 重原子数：
  23.0
• 可旋转键数：
  5.0
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.21
• 拓扑面积：
  22.12
• 氢给体数：
  0.0
• 氢受体数：
  3.0

反应信息

• 作为反应物：
  描述：

  2-((benzyloxy)(4-bromophenyl)methyl)-4,5-dimethylthiazole 、 碘甲烷 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones

  摘要：

  A new NHCs-mediated synthetic method was found to produce alpha-aryl ketones in 22-63% yields in one-pot process from the corresponding aromatic aldehydes and benzyl halides. This method is the first example of the NHCs-mediated intermolecular nucleophilic acylation of aromatic aldehydes with benzyl halides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.003
• 作为产物：
  描述：

  (4-bromophenyl)(4,5-dimethylthiazol-2-yl)methanol 、 溴甲苯 在 sodium hydride 作用下， 以 四氢呋喃 为溶剂， 生成 2-((benzyloxy)(4-bromophenyl)methyl)-4,5-dimethylthiazole
  参考文献：
  名称：

  The NHCs-mediated cross-coupling of aromatic aldehydes with benzyl halides: synthesis of α-aryl ketones

  摘要：

  A new NHCs-mediated synthetic method was found to produce alpha-aryl ketones in 22-63% yields in one-pot process from the corresponding aromatic aldehydes and benzyl halides. This method is the first example of the NHCs-mediated intermolecular nucleophilic acylation of aromatic aldehydes with benzyl halides. (C) 2010 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2010.05.003