diethyl 2-phosphonopropionate | 123226-43-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: diethyl 2-phosphonopropionate
• 英文别名: Ethoxy-(1-ethoxy-1-oxopropan-2-yl)phosphinic acid
• CAS: 123226-43-7
• 化学式: C₇H₁₅O₅P
• 分子量: 210.167
• InChiKey: KWCKSBYVBOQFNY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  13
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  72.8
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  4-苄氧基苯甲醛 、 diethyl 2-phosphonopropionate 以 四氢呋喃 为溶剂， 生成 (E)-3-(4-benzyloxyphenyl)-2-methylacrylic acid ethyl ester
  参考文献：
  名称：

  Quinoline derivatives and their use as antagonists of leukotriene D.sub.4

  摘要：

  本发明涉及喹啉基二芳基化合物及其作为白三烯D.sub.4拮抗剂治疗过敏性疾病的用途。

  公开号：

  US05059610A1

文献信息

• Therapeutic uses of PPAR mediators
  申请人：——

  公开号：US20030220373A1

  公开（公告）日：2003-11-27

  Use of PPAR mediators, and their pharmaceutical compositions, as ATP binding cassette transporter 1 (ABC-1) expression modulators, wherein the PPAR ligand receptor agonists of this invention are useful as inducers of ABC-1 expression.

  使用PPAR介质及其制药组合物作为ATP结合盒转运蛋白1（ABC-1）表达调节剂，本发明的PPAR配体受体激动剂可作为ABC-1表达的诱导剂。
• Therapeutic uses of quinoline derivatives
  申请人：Aventis Pharma Deutschland GmbH

  公开号：US06376512B1

  公开（公告）日：2002-04-23

  A method for mediating the activity of PPAR-&ggr; receptor comprising contacting said PPAR-&ggr; receptor with a compound of formula I defined herein. Also disclosed is the treatment of a patient suffering from a physiological disorder capable of being modulated by a compound of formula I having PPAR-&ggr; ligand binding activity, comprising administering to the patient a pharmaceutically acceptable amount of the compound, or a pharmaceutically acceptable salt thereof.

  一种调节PPAR-γ受体活性的方法，包括将所述PPAR-γ受体与本文定义的I式化合物接触。还公开了治疗患有可被具有PPAR-γ配体结合活性的I式化合物调节的生理紊乱的患者的方法，包括向患者施用药学上可接受的量的该化合物或其药学上可接受的盐。
• Quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same
  申请人：RHONE-POULENC RORER INTERNATIONAL (HOLDINGS) INC.

  公开号：EP0315399A2

  公开（公告）日：1989-05-10

  This invention relates to quinoline derivatives, their use in the treatment of hypersensitive ailments and a pharmaceutical composition containing the same. The quinoline derivatives of the invention are a particular class of quinolinyl-diaryl compounds and they are especially valuable as lipoxygenase inhibitors and/or leukotriene antagonists, typically antagonists of leukotriene D4, possessing anti-inflammatory and anti-allergic properties.

  本发明涉及喹啉衍生物、它们在治疗过敏性疾病中的用途以及含有喹啉衍生物的药物组合物。 本发明的喹啉衍生物是一类特殊的喹啉基二元化合物，它们作为脂氧合酶抑制剂和/或白三烯拮抗剂（通常是白三烯 D4 拮抗剂）特别有价值，具有抗炎和抗过敏特性。
• FLAME-RETARDANT POLYBUTYLENE TEREPHTHALATE RESIN COMPOSITION, AND MOLDED PRODUCT THEREOF
  申请人：Wintech Polymer Ltd.

  公开号：EP2927279A1

  公开（公告）日：2015-10-07

  Provided are: a flame-retardant polybutylene terephthalate resin composition which exhibits excellent flame retardance, glow-wire properties (GWIT), tracking resistance and bleed resistance in spite of a fact that a polybutylene terephthalate resin is used as a sole resin component; and a molded product of the resin composition. A flame-retardant polybutylene telephthalate resin composition containing (A) a polybutylene telephthalate resin, (B) a phosphinic acid salt, (C) a phosphazene compound, and (D) a nitrogen-containing cyclic compound, which exhibits a flame retardance in accordance with a UL94 flammability test of V-0, a glow-wire ignition temperature (GWIT) in accordance with IEC60695-2-13 standard of 775°C or more, and a comparative tracking index (CTI) in accordance with IEC60112 standard of 400 V or more, and bleed out does not occur when the composition is treated at 110°C for 20 hours.

  本文提供了：一种阻燃性聚对苯二甲酸丁二醇酯树脂组合物，该组合物在使用聚对苯二甲酸丁二醇酯树脂作为唯一树脂成分的情况下仍能表现出优异的阻燃性、萤光丝特性（GWIT）、耐跟踪性和抗渗漏性；以及该树脂组合物的模塑产品。一种阻燃性聚对苯二甲酸丁二醇酯树脂组合物，含有(A)聚对苯二甲酸丁二醇酯树脂、(B)膦酸盐、(C)磷苯化合物和(D)含氮环状化合物，其阻燃性能符合 UL94 易燃性测试 V-0、根据 IEC60695-2-13 标准，其辉光丝点火温度（GWIT）为 775°C 或以上，根据 IEC60112 标准，其比较跟踪指数（CTI）为 400 V 或以上，且在 110°C 下处理 20 小时不会发生渗出。
• THERAPEUTIC USES OF QUINOLINE DERIVATIVES
  申请人：Aventis Pharmaceuticals Products Inc.

  公开号：EP1030665A1

  公开（公告）日：2000-08-30