2-ethyl-N-{3-fluoro-4-[4-((R)-pyridin-2-yl-tetrahydro-furan-2-yl-methyl)-piperazin-1-yl]-phenyl}-butyramide | 1141884-35-6

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪烷类
• 英文名称: 2-ethyl-N-{3-fluoro-4-[4-((R)-pyridin-2-yl-tetrahydro-furan-2-yl-methyl)-piperazin-1-yl]-phenyl}-butyramide
• 英文别名: 2-ethyl-N-[3-fluoro-4-[4-[[(2R)-oxolan-2-yl]-pyridin-2-ylmethyl]piperazin-1-yl]phenyl]butanamide
• CAS: 1141884-35-6
• 化学式: C₂₆H₃₅FN₄O₂
• 分子量: 454.588
• InChiKey: ALLJIQWTWZINEO-IKOFQBKESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  33
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  57.7
• 氢给体数：
  1
• 氢受体数：
  6

文献信息

• ORGANIC COMPOUNDS
  申请人：Nozulak Joachim

  公开号：US20090099199A1

  公开（公告）日：2009-04-16

  The invention relates to compound of the formula I wherein the substituents are as defined in the specification; in free base form or in acid addition salt form; to its preparation, to its use as medicament and to medicaments comprising it.

  这项发明涉及公式I的化合物 其中取代基如规范中定义；以自由碱形式或酸盐形式存在；其制备，用作药物以及包含它的药物。
• SUBSTITUTED PIPERAZINES AND PIPERIDINES AS MODULATORS OF THE NEUROPEPTIDE Y2 RECEPTOR
  申请人：Novartis AG

  公开号：EP2205561A2

  公开（公告）日：2010-07-14
• [EN] ORGANIC COMPOUNDS<br/>[FR] COMPOSÉS ORGANIQUES
  申请人：NOVARTIS AG

  公开号：WO2009050197A2

  公开（公告）日：2009-04-23

  The invention relates to compound of the formula (I): wherein the substituents are as defined in the specification; in free base form or in acid addition salt form; to its preparation, to its use as medicament and to medicaments comprising it.