(4aS,8aR,9aS)-3-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-8amethyl-5-methylidene-2,4,4a,5,6,7,8,8a,9,9a-decahydronaphtho[2,3-b]furan-2-one | 1523436-92-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: (4aS,8aR,9aS)-3-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-8amethyl-5-methylidene-2,4,4a,5,6,7,8,8a,9,9a-decahydronaphtho[2,3-b]furan-2-one
• 英文别名: (4As,8ar,9as)-3-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-8a-methyl-5-methylidene-2,4,4a,5,6,7,8,8a,9,9a-deca-hydronaphtho[2,3-b]furan-2-one；5-[[(4aS,8aR,9aS)-8a-methyl-5-methylidene-2-oxo-4a,6,7,8,9,9a-hexahydro-4H-benzo[f][1]benzofuran-3-yl]methyl]-1,3-dimethylpyrimidine-2,4-dione
• CAS: 1523436-92-1
• 化学式: C₂₁H₂₆N₂O₄
• 分子量: 370.448
• InChiKey: QHOOQUNYEHNAIA-XGHQBKJUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.9
• 重原子数：
  27
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  66.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  异土木香内酯 、 5-碘-1,3-的甲基尿嘧啶 在 四丁基氯化铵 、 palladium diacetate 、 三乙胺 、 三(邻甲基苯基)磷 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 以9%的产率得到(4aS,8aR,9aS)-3-[(1,3-dimethyl-2,4-dioxo-1,2,3,4-tetrahydropyrimidin-5-yl)methyl]-8amethyl-5-methylidene-2,4,4a,5,6,7,8,8a,9,9a-decahydronaphtho[2,3-b]furan-2-one
  参考文献：
  名称：

  Synthetic transformations of sesquiterpene lactones: VII. Palladium-catalyzed cross-coupling of isoalantolactone with 5-halouracils

  摘要：

  Palladium-catalyzed cross-coupling of isoalantolactone with 1,3-disubstituted or 1-substituted 5-bromo(iodo)uracils afforded mainly (13E)-13-(2,4-dioxotetrahydropyrimidin-5-yl)eudesma-4(15),11(13)-dien-8 beta,12-olides whose yields depended on the composition of the catalytic system, base, and additive. The structure of (13E)-13-[3-(2-cyanoethyl)-2,4-dioxotetrahydropyrimidin-5-yl]eudesma-4(15),11(13)-dien-8 beta,12-olide was proved by X-ray analysis.

  DOI：

  10.1134/s1070428013120130