2-propenyl-phenetole | 67191-37-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-propenyl-phenetole
• 英文别名: α-(2-Aethoxy-phenyl)-α-propylen；2-Aethoxy-1-propenyl-benzol；2-Propenyl-phenetol；o-Propenyl-phenetol；1-ethoxy-2-(1-propenyl)-benzene；1-(2-Propenyl)-2-ethoxybenzol；1-Ethoxy-2-prop-1-enylbenzene
• CAS: 67191-37-1
• 化学式: C₁₁H₁₄O
• 分子量: 162.232
• InChiKey: OPZFSCVNURAGAJ-UHFFFAOYSA-N

物化性质

• 沸点：
  231°C (estimate)
• 密度：
  0.9731

计算性质

• 辛醇/水分配系数(LogP)：
  3.3
• 重原子数：
  12
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.27
• 拓扑面积：
  9.2
• 氢给体数：
  0
• 氢受体数：
  1

反应信息

• 作为反应物：
  描述：

  2-propenyl-phenetole 在 甲酸 、 乙醇 、 aluminium amalgam 、 水 、 双氧水 、 丙酮 作用下， 生成 [2-(2-乙氧基-苯基)-1-甲基-乙基]-甲基-胺
  参考文献：
  名称：

  Horii; Inoi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1957, vol. 77, p. 1095,1099

  摘要：

  DOI：
• 作为产物：
  描述：

  2-乙氧基苯甲醛 在 盐酸 作用下， 生成 2-propenyl-phenetole
  参考文献：
  名称：

  Antifungal Pharmacodynamic Characteristics of Amphotericin B againstTrichosporon asahii, Using Time-Kill Methodology

  摘要：

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.

  DOI：

  10.1111/j.1348-0421.2002.tb02663.x

文献信息

• Method for oxidizing unsaturated aromatic compounds
  申请人：NIPPON PETROCHEMICALS COMPANY, LIMITED

  公开号：EP0350069A2

  公开（公告）日：1990-01-10

  This invention relates to a method for manufacturing aromatic compounds having the following formula (II) comprising the step of reacting an unsaturated aromatic compound having the following formula (I) with an aryl compound containing an iodosyl group or the salt thereof within a temperature range of from -50 to 200oC:

  本发明涉及一种制造具有下式（II）的芳香族化合物的方法，该方法包括以下步骤：将具有下式（I）的不饱和芳香族化合物与含有碘代基团的芳基化合物或其盐在-50 至 200 摄氏度的温度范围内进行反应：
• Antifungal Pharmacodynamic Characteristics of Amphotericin B against<i>Trichosporon asahii</i>, Using Time-Kill Methodology
  作者：Yoshimi Toriumi、Takashi Sugita、Masamitsu Nakajima、Toshiharu Matsushima、Takako Shinoda

  DOI：10.1111/j.1348-0421.2002.tb02663.x

  日期：2002.2

  AbstractWe determined the MIC of amphotericin B against 45 Trichosporon asahii isolates from various clinical and environmental sources, and used in vitro time‐kill methods to characterize the relationship between amphotericin B concentrations and MIC for four representative T. asahii isolates. Amphotericin B had concentration‐dependent antifungal activity. MICs ranged from 0.5 to 16 μg/ml, and most T. asahii isolates (76%, 34/45) were inhibited at safely achievable amphotericin B serum concentrations (≤ 2 μg/ml). However, 40% (18/45) of isolates were not killed at these concentrations (MFCs from 1.0 to 32 μg/ml). At concentrations ≥ 2 × MIC, amphotericin B exhibited fungicidal activity (< 99.9% reduction in CFU) over a 12‐hr time‐period; the maximal effect was achieved at ≥ 4 × MIC. Susceptibility testing confirmed the resistance of T. asahii to amphotericin B, and in vitro pharmacodynamic results also suggest that amphotericin B is not suitable therapy for T. asahii infection.
• Horii; Inoi, Yakugaku Zasshi/Journal of the Pharmaceutical Society of Japan, 1957, vol. 77, p. 1095,1099
  作者：Horii、Inoi

  DOI：——

  日期：——