(R)-5-methylhepta-3,4-dien-1-ol | 308143-42-2

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (R)-5-methylhepta-3,4-dien-1-ol
• CAS: 308143-42-2
• 化学式: C₈H₁₄O
• 分子量: 126.199
• InChiKey: WTSQDKCVGMAJSM-LURJTMIESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.88
• 重原子数：
  9.0
• 可旋转键数：
  3.0
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  20.23
• 氢给体数：
  1.0
• 氢受体数：
  1.0

反应信息

• 作为反应物：
  描述：

  (R)-5-methylhepta-3,4-dien-1-ol 在 potassium carbonate 作用下， 以 甲醇 、 二氯甲烷 为溶剂， 生成
  参考文献：
  名称：

  Chemoselective Allene Aziridination via Ag(I) Catalysis

  摘要：

  Allene aziridination generates useful bicyclic methylene aziridine scaffolds that can be flexibly transformed into a range of stereochemically complex and densely functionalized amine-containing stereotriads. The scope of this chemistry has been limited by the poor chemoselectivity that often results when typical dinuclear Rh(II) catalysts are employed with homoallenic carbamates. Herein, Ag(I) catalysts that significantly improve the scope and yield of bicyclic methylene aziridines that can be prepared via allene aziridination are described.

  DOI：

  10.1021/ol303167n

文献信息

• Stereocontrolled Syntheses of Seven-Membered Carbocycles by Tandem Allene Aziridination/[4+3] Reaction
  作者：Nels C. Gerstner、Christopher S. Adams、Maik Tretbar、Jennifer M. Schomaker

  DOI：10.1002/anie.201606195

  日期：2016.10.10

  A tandem allene aziridination/[4+3]/reduction sequence converts simple homoallenic sulfamates into densely functionalized aminated cycloheptenes, where the relative stereochemistry at five contiguous asymmetric centers can be controlled through the choice of the solvent and the reductant. The products resulting from this chemistry can be readily transformed into complex molecular scaffolds which contain

  串联丙二烯氮丙啶化/[4+3]/还原序列将简单的同丙二烯氨基磺酸盐转化为密集官能化的胺化环庚烯，其中五个连续不对称中心的相对立体化学可以通过选择溶剂和还原剂来控制。这种化学反应产生的产物可以很容易地转化为复杂的分子支架，其中包含多达七个连续的立体中心。