cycloheptane-1,2-dicarboxylicacid | 3603-87-0

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: cycloheptane-1,2-dicarboxylicacid
• 英文别名: 1,2-Cycloheptandicarbonsaeure；Cycloheptan-1,2-dicarbonsaeure；1,2-Cycloheptanedicarboxylic acid；cycloheptane-1,2-dicarboxylic acid
• CAS: 3603-87-0
• 化学式: C₉H₁₄O₄
• 分子量: 186.208
• InChiKey: PTKFWXSRNGLQIH-UHFFFAOYSA-N

物化性质

• 熔点：
  165-166 °C
• 沸点：
  392.3±35.0 °C(Predicted)
• 密度：
  1.252±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  74.6
• 氢给体数：
  2
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  cycloheptane-1,2-dicarboxylicacid 在 lithium aluminium tetrahydride 作用下， 以 四氢呋喃 为溶剂， 反应 8.0h， 生成 (cycloheptane-1,2-diyl)dimethanol
  参考文献：
  名称：

  环状硫代磺酸盐衍生的抗癌剂：结构-反应性和结构-活性关系

  摘要：

  交换动态：据报道，环状硫代磺酸盐分子（二硫键破坏剂 (DDA)）的结构-性质-功能关系，可同时下调表皮生长因子受体 (HER) 家族，并选择性诱导 EGFR+ 或 HER2+ 乳腺癌细胞凋亡。最近显示，DDA 与选定的蛋白质二硫键异构酶 (PDI) 的活性位点半胱氨酸残基共价结合。如图所示，DDA 的结构修饰可以调节硫醇-硫代磺酸盐交换反应的动力学，并产生更有效的化合物。

  DOI：

  10.1002/cmdc.202200165
• 作为产物：
  描述：

  2-氧-1-环辛烷羧酸 在 氢氧化钾 、 溴 作用下， 生成 cycloheptane-1,2-dicarboxylicacid
  参考文献：
  名称：

  天然存在的内酯和内酰胺-V：卤代β-酮酯作为合成四氢代酸的起始原料

  摘要：

  为了改善和简化合成四氢萘甲酸的合成途径，研究了15种不同取代的β-酮酯作为潜在的原料。将β-酮酸酯溴化并用2·5 N KOH作为环化剂环化。获得了Tetronic酸和七种衍生物，包括天然存在的卡罗琳酸。在许多情况下，都分离了由Favorskii重排产生的产品。讨论了NMR光谱数据。

  DOI：

  10.1016/0040-4020(73)80266-2

文献信息

• DEODORANTS
  申请人：Kao Corporation

  公开号：EP1197204A1

  公开（公告）日：2002-04-17

  The present invention provides a liquid deodorant suitable for deodorization of spaces and fiber products, and a hair cosmetic and skin cosmetic having a high deodorization effect. Here, any of the hair cosmetic and skin cosmetic may be that referred to as a body deodorant. Namely, the present invention provides a deodorant comprising a deodorant organic dibasic acid composed of an organic dibasic acid and/or salt thereof having a difference between the first acid dissociation index (hereinafter, abbreviated as first acid dissociation index) and the second acid dissociation index (hereinafter, abbreviated as second acid dissociation index or pK2) of 1.7 or more at 25°C.

  本发明提供了一种适用于空间和纤维制品除臭的液体除臭剂，以及一种具有高除臭效果的头发化妆品和皮肤化妆品。在此，头发化妆品和皮肤化妆品中的任何一种都可以被称为身体除臭剂。也就是说，本发明提供了一种除臭剂，该除臭剂包含由有机二元酸和/或其盐组成的除臭有机二元酸，在 25°C 时，其第一酸解离指数（以下简称第一酸解离指数）与第二酸解离指数（以下简称第二酸解离指数或 pK2）之差为 1.7 或以上。
• METHOD FOR PRODUCING SOLID CATALYST COMPONENT FOR USE IN POLYMERIZATION OF OLEFIN, CATALYST FOR USE IN POLYMERIZATION OF OLEFIN, AND METHOD FOR PRODUCING OLEFIN POLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP2876118A1

  公开（公告）日：2015-05-27

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds selected from specific aromatic dicarboxylic diesters into contact with each other to effect a reaction, followed by washing, a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing, and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种选自特定芳香族二羧酸二酯的第一内部电子供体化合物相互接触以发生反应，然后进行洗涤、第二步：使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；第三步：使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• PRODUCTION METHOD FOR SOLID CATALYST COMPONENT FOR POLYMERIZING OLEFINS, CATALYST FOR POLYMERIZING OLEFINS, AND PRODUCTION METHOD FOR POLYMERIZED OLEFINS
  申请人：TOHO TITANIUM CO., LTD.

  公开号：EP2963063A1

  公开（公告）日：2016-01-06

  A method for producing a solid catalyst component for olefin polymerization produces a novel solid catalyst component for olefin polymerization that achieves excellent olefin polymerization activity and activity with respect to hydrogen during polymerization, and can produce an olefin polymer that exhibits a high MFR, high stereoregularity, and excellent rigidity. The method includes a first step that brings a magnesium compound, a tetravalent titanium halide compound, and one or more first internal electron donor compounds excluding an aromatic dicarboxylic acid diester into contact with each other to effect a reaction, followed by washing; a second step that brings a tetravalent titanium halide compound and one or more second internal electron donor compounds into contact with a product obtained by the first step to effect a reaction, followed by washing; and a third step that brings one or more third internal electron donor compounds into contact with a product obtained by the second step to effect a reaction.

  一种生产烯烃聚合用固体催化剂组分的方法可生产出一种新型的烯烃聚合用固体催化剂组分，该组分具有优异的烯烃聚合活性和聚合过程中对氢的活性，并可生产出具有高MFR、高立体规整度和优异刚性的烯烃聚合物。该方法包括第一步，使镁化合物、四价卤化钛化合物和一种或多种第一内部电子供体化合物（不包括芳香族二羧酸二酯）相互接触以发生反应，然后进行洗涤；第二步，使四价卤化钛化合物和一种或多种第二内部电子供体化合物与第一步得到的产物接触，以发生反应，然后进行洗涤；以及第三步，使一种或多种第三内部电子供体化合物与第二步得到的产物接触，以发生反应。
• CATALYST FOR OLEFIN POLYMERIZATION, METHOD FOR PRODUCING OLEFIN POLYMER, AND PROPYLENE/ -OLEFIN COPOLYMER
  申请人：Toho Titanium Co., Ltd.

  公开号：EP3623393A1

  公开（公告）日：2020-03-18

  Provided is a catalyst for polymerization of an olefin which can prepare, with high productivity, a polymer having excellent hydrogen activity and high stereoregularity and MFR even in homopolymerization at a high temperature, and is also capable of producing a copolymer that achieves excellent hydrogen activity and copolymerization activity even in copolymerization at a high temperature and is excellent in impact resistance. The present invention provides a catalyst for polymerization of an olefin, comprising a compound represented by the general formula R1R2Si(NHR3)2 wherein R1 is a cycloalkyl group having 3 to 12 carbon atoms or an aromatic hydrocarbon group having 6 to 12 carbon atoms; R2 is a linear alkyl group having 1 to 10 carbon atoms or a branched alkyl group having 3 to 10 carbon atoms; the number of carbon atoms of R1 is larger by 2 or more than that of R2; and R3 is a linear alkyl group having 2 to 6 carbon atoms, a branched alkyl group having 3 to 6 carbon atoms or a cycloalkyl group having 3 to 6 carbon atoms, as an external electron-donating compound.

  本发明提供了一种用于烯烃聚合的催化剂，它能以高生产率制备即使在高温下均聚时也具有优异氢活性和高立体规整度及MFR的聚合物，还能制备即使在高温下共聚时也具有优异氢活性和共聚活性以及优异抗冲击性的共聚物。本发明提供了一种用于烯烃聚合的催化剂，包括通式 R1R2Si(NHR3)2 所代表的化合物 其中 R1 是具有 3 至 12 个碳原子的环烷基或具有 6 至 12 个碳原子的芳香烃基；R2 是具有 1 至 10 个碳原子的直链烷基或具有 3 至 10 个碳原子的支链烷基；R1 的碳原子数比 R2 的碳原子数多 2 个或 2 个以上；以及 R3 是具有 2 至 6 个碳原子的直链烷基、具有 3 至 6 个碳原子的支链烷基或具有 3 至 6 个碳原子的环烷基，作为外部电子供体化合物。
• CATALYST FOR OLEFIN POLYMERIZATION, METHOD FOR PRODUCING CATALYST FOR OLEFIN POLYMERIZATION, METHOD FOR PRODUCING OLEFIN POLYMER, AND PROPYLENE- -OLEFIN COPOLYMER
  申请人：Toho Titanium CO., LTD.

  公开号：EP3689918A1

  公开（公告）日：2020-08-05

  Provided is a catalyst for polymerization of an olefin which is excellent in sustained polymerization activity in the polymerization of an α-olefin and is capable of preferably producing an α-olefin (co)polymer having high stereoregularity and MFR and favorable moldability. The present invention provides a catalyst for polymerization of an olefin, comprising: a solid catalyst component containing magnesium, titanium, halogen and an internal electron-donating compound; an organoaluminum compound; and external electron-donating compounds being of two types of alkoxysilane compounds having specific structures represented by the general formula (I) and the general formula (II), respectively, wherein the catalyst for polymerization of an olefin comprises 51 to 99% by mol of the external electron-donating compound represented by the general formula (I) and 1 to 49% by mol of the external electron-donating compound represented by the general formula (II) with respect to the total amount of both the external electron-donating compounds.

  本发明提供了一种用于烯烃聚合的催化剂，它在α-烯烃聚合中具有优异的持续聚合活性，并且能够优选生产具有高立体规整度和 MFR 以及良好成型性的α-烯烃（共）聚合物。本发明提供了一种用于烯烃聚合的催化剂，包括含有镁、钛、卤素和内部电子供体化合物的固体催化剂组分； 有机铝化合物；通式(Ⅰ)和通式(Ⅱ)分别代表的两种烷氧基硅烷化合物，其中烯烃聚合催化剂包含通式(Ⅰ)代表的外部电子赋 予化合物 51%至 99%（摩尔）和通式(Ⅱ)代表的外部电子赋予化合物 1%至 49%（摩尔）。