(2,4-dichloro-phenyl)-[5-((S)-2-phenyl-morpholin-4-ylmethyl)-pyridin-2-yl]-amine | 1020673-40-8

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: (2,4-dichloro-phenyl)-[5-((S)-2-phenyl-morpholin-4-ylmethyl)-pyridin-2-yl]-amine
• 英文别名: (S)-N-(2,4-dichlorophenyl)-5-((2-phenylmorpholino)methyl)pyridin-2-amine；N-(2,4-dichlorophenyl)-5-[[(2S)-2-phenylmorpholin-4-yl]methyl]pyridin-2-amine
• CAS: 1020673-40-8
• 化学式: C₂₂H₂₁Cl₂N₃O
• 分子量: 414.334
• InChiKey: UEQFDKPJVORYNS-OAQYLSRUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  28
• 可旋转键数：
  5
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.23
• 拓扑面积：
  37.4
• 氢给体数：
  1
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  (S)-4-(6-chloropyridin-3-methyl)-2-phenyl-morpholine 、 2,4-二氯苯胺 在 sodium hexamethyldisilazane 作用下， 以 二甲基亚砜 为溶剂， 生成 (2,4-dichloro-phenyl)-[5-((S)-2-phenyl-morpholin-4-ylmethyl)-pyridin-2-yl]-amine
  参考文献：
  名称：

  Morpholine containing CB2 selective agonists

  摘要：

  Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.02.033

文献信息

• Compounds Which Modulate The CB2 Receptor
  申请人：Riether Doris

  公开号：US20100029644A1

  公开（公告）日：2010-02-04

  Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.

  公式（I）的化合物已被披露。本发明的化合物是CB2受体的激动剂、拮抗剂或反向激动剂，并可用于治疗炎症。那些是激动剂的化合物还可用于治疗疼痛。
• US7928103B2
  申请人：——

  公开号：US7928103B2

  公开（公告）日：2011-04-19
• [EN] POLYCYCLIC COMPOUNDS WHICH MODULATE THE CB2 RECEPTOR<br/>[FR] COMPOSÉS QUI MODULENT LE RÉCEPTEUR CB2
  申请人：BOEHRINGER INGELHEIM INT

  公开号：WO2008048914A1

  公开（公告）日：2008-04-24

  [EN] Compounds of formula (I) are disclosed. Compounds according to the invention are agonists, antagonists or inverse agonists of the CB2 receptor, and are useful for treating inflammation. Those compounds which are agonists are additionally useful for treating pain.
  [FR] La présente invention concerne des composés répondant à la formule (I). Les composés selon l'invention sont des agonistes, des antagonistes ou des agonistes inverses du récepteur CB2, et ils se révèlent utiles pour le traitement d'une inflammation. Les composés qui s'avèrent être des agonistes sont en outre utiles pour le traitement de la douleur.
• Morpholine containing CB2 selective agonists
  作者：Renée Zindell、Doris Riether、Todd Bosanac、Angela Berry、Mark J. Gemkow、Andreas Ebneth、Sabine Löbbe、Ernest L. Raymond、Diane Thome、Daw-Tsun Shih、David Thomson

  DOI：10.1016/j.bmcl.2009.02.033

  日期：2009.3

  Identification and optimization of two classes of CB2 selective agonists are described. A representative from each class is profiled in a murine model of inflammation and each shows similar efficacy to prednisolone upon oral dosing. (C) 2009 Elsevier Ltd. All rights reserved.