4-吗啉甲酰胺-N-(2-氨基乙基)盐酸盐 | 88017-03-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 中文名称: 4-吗啉甲酰胺-N-(2-氨基乙基)盐酸盐
• 英文名称: 2-(morpholine-4-carboxamido)ethanamino hydrochloride
• 英文别名: 2-(morpholin-4-carboxamido)ethylamine hydrochloride；N-(2-aminoethyl)-4-morpholinecarboxamide hydrochloride；N-(2-Aminoethyl)morpholine-4-carboxamide hydrochloride；N-(2-aminoethyl)morpholine-4-carboxamide;hydrochloride
• CAS: 88017-03-2
• 化学式: C₇H₁₅N₃O₂*ClH
• 分子量: 209.676
• InChiKey: IBHMRVSCIXUNHL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.59
• 重原子数：
  13
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  67.6
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  4-吗啉甲酰胺-N-(2-氨基乙基)盐酸盐 、 (S)-(2,2-dimethyl-1,3-dioxolan-4-yl)methyl 3-(4-((2R)-3-chloro-2-hydroxypropoxy)phenyl)propanoate 在 sodium hydroxide 作用下， 以 异丙醇 为溶剂， 反应 2.0h， 以55.6%的产率得到兰地洛尔
  参考文献：
  名称：

  란디올롤의 거울상선택적 합성 방법

  摘要：

  The method for producing randiolol 1, namely ((S)-2,2-dimethyl-1,3-dioxolane-4-yl)methyl 3-(4-((S)-2-hydroxy-3-(2-(morpholin-4-carboxamido)ethylamino)propoxy)phenyl)propanoate, as an alkylating agent with an epoxide structure, starting from 2-(morpholin-4-carboxamido)ethanamine, especially epichlorohydrin, and 2-(morpholin-4-carboxamido)ethanamine in the form of a glass base or its salt form. The method is carried out without separating most of the intermediates, does not require a purification process using chromatography, and has advantages in terms of yield and productivity. Additionally, the resulting randiolol can be easily converted into randiolol hydrochloride, which is particularly pure and has a high enantiomeric purity.

  公开号：

  KR101862824B1

文献信息

• Method for the synthesis of pharmacologically active compounds and
  申请人：Aktiebolaget Hassle

  公开号：US04777293A1

  公开（公告）日：1988-10-11

  A process for the preparation of an aryloxypropanolamine of the formula Ar--OCH.sub.2 CH(OH)CH.sub.2 NH--R I wherein Ar is a carbocyclic or heterocyclic aromatic group and R is an alkyl or substituted alkyl group having 1 to 6 carbon atoms, characterized in subjecting a compound of the formula ##STR1## to oxidative cleavage to a dialdehyde of the formula ##STR2## which is then made subject to reduction, amination, acetal hydrolysis, and, where required, removal of a nitrogen protective group, to the formation of a compound of formula I, or an acid addition salt thereof, a compound of formula II and the preparation thereof from mannitol.

  一种制备式为Ar-OCH2CH(OH)CH2NH-R I的芳氧基丙醇胺的方法，其中Ar是环烃或杂环芳香基团，R是具有1至6个碳原子的烷基或取代烷基团，其特征在于将式为##STR1##的化合物进行氧化裂解成式为##STR2##的二醛，然后进行还原、胺化、缩醛水解和必要时去除氮保护基，以形成式I的化合物或其酸加成盐，以及式II的化合物及其从甘露醇制备的方法。
• "Process for the enantioselective synthesis of landiolol"
  申请人：Procos S.p.A.

  公开号：EP2687521B1

  公开（公告）日：2015-01-07
• Method for the synthesis of pharmacologically active aryloxypropanol amine compounds
  申请人：Aktiebolaget Hässle

  公开号：EP0179031B1

  公开（公告）日：1989-01-18
• US4777293A
  申请人：——

  公开号：US4777293A

  公开（公告）日：1988-10-11