Acetic acid 2-(1H-indol-4-yloxy)-1-(4-phenoxymethyl-piperidin-1-ylmethyl)-ethyl ester | 67160-17-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: Acetic acid 2-(1H-indol-4-yloxy)-1-(4-phenoxymethyl-piperidin-1-ylmethyl)-ethyl ester
• 英文别名: [1-(1H-indol-4-yloxy)-3-[4-(phenoxymethyl)piperidin-1-yl]propan-2-yl] acetate
• CAS: 67160-17-2
• 化学式: C₂₅H₃₀N₂O₄
• 分子量: 422.524
• InChiKey: QTXDQSRTGFBZPR-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.4
• 拓扑面积：
  63.8
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• Carvedilol-galenics
  申请人：——

  公开号：US20030118643A1

  公开（公告）日：2003-06-26

  The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70% after 30 minutes, prepared in accordance with the process of the invention.

  该发明涉及一种从难溶性活性物质制备快速溶解药物制剂的方法，其中从活性物质和一种或多种水溶性辅助剂制备出水悬浮液，然后通过常规方法处理所得的水悬浮液，去除水分，形成固体药物制剂。该发明还涉及根据该方法制备的具有至少70%溶解率的活性物质的快速溶解药物制剂，经过30分钟后。
• CARVEDILOL-GALENICS
  申请人：Roche Diagnostics GmbH

  公开号：EP1069896A1

  公开（公告）日：2001-01-24
• US4146630A
  申请人：——

  公开号：US4146630A

  公开（公告）日：1979-03-27
• US6852337B2
  申请人：——

  公开号：US6852337B2

  公开（公告）日：2005-02-08
• [EN] CARVEDILOL-GALENICS<br/>[FR] MEDICAMENTS GALENIQUES A BASE DE CARVEDILOL
  申请人：ROCHE DIAGNOSTICS GMBH

  公开号：WO1999052526A1

  公开（公告）日：1999-10-21

  (EN) The invention relates to a process for the preparation of fast-dissolving pharmaceutical preparations from difficultly soluble active substances, wherein an aqueous suspension is made from the active substance and one or more water-soluble adjuvants and then the resulting aqueous suspension is processed, with removal of the water, by methods conventional per se, to form solid pharmaceutical preparations. The invention also relates to fast-dissolving pharmaceutical preparations of active substances having a dissolution rate of at least 70 % after 30 minutes, prepared in accordance with the process of the invention.(FR) L'invention se rapporte à un procédé de préparation de compositions pharmaceutiques à dissolution rapide à partir de substances actives difficilement solubles, selon lequel on prépare une suspension aqueuse à partir de la substance active et d'un ou de plusieurs adjuvants hydrosolubles puis on traite la suspension aqueuse (après en avoir évacué l'eau) par des procédés connus afin de former des préparations pharmaceutiques solides. L'invention se rapporte également à des préparations pharmaceutiques à dissolution rapide, obtenues à partir de substances actives possédant un taux de dissolution d'au moins 70 % en trente minutes. Ces préparations sont fabriquées selon le procédé de l'invention.