5,10,15,20-tetra(2,3-benzo-1,4-dioxa-2-cyclopenten-4'-yl)porphyrin | 17260-23-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 四吡咯及其衍生物
• 英文名称: 5,10,15,20-tetra(2,3-benzo-1,4-dioxa-2-cyclopenten-4'-yl)porphyrin
• CAS: 17260-23-0
• 化学式: C₄₈H₃₀N₄O₈
• 分子量: 790.788
• InChiKey: BTOLHHOZXZUGOB-XPLYENQYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  10.24
• 重原子数：
  60.0
• 可旋转键数：
  4.0
• 环数：
  13.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  131.2
• 氢给体数：
  2.0
• 氢受体数：
  10.0

反应信息

• 作为反应物：
  描述：

  5,10,15,20-tetra(2,3-benzo-1,4-dioxa-2-cyclopenten-4'-yl)porphyrin 在 iron(II) chloride tetrahydrate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 生成
  参考文献：
  名称：

  Use of iron and manganese porphyrins in solution and immobilized on silica obtained by the sol–gel process as catalyst in the oxidation of organic substrates

  摘要：

  The preparation and characterization of the metalloporphyrins [Fe(TAPP)]CI, 5,10,15,20-tetrakis(acetalphenyl porphyrin) iron(III) chloride, and [Mn(TAPP)]Ac, 5,10,15,20-tetrakis (acetalphenyl porphyrin) manganese(III) acetate and of the solids obtained by their heterogenization in silica obtained by the sol-gel process in acidic and basic media are reported. The compounds were characterized by ultraviolet-visible absorption spectroscopy (UV-vis), X-ray diffraction (XRD), infrared spectroscopy (FTIR), electron paramagnetic resonance (ERR), and thermogravimetric analysis (TGA). The catalytic activity of the metalloporphyrins in solution and as heterogeneous catalysts concerning the oxidation of organic substrates like cyclooctene and cyclohexane was investigated. The catalysts employed here, which consist of reasonably low-cost metalloporphyrins with intermediate structure between first- and second-generation porphyrins, furnished promising results. These novel solid materials offered benefits such as higher product yields, compared to the first-generation catalysts, and inexpensive preparation routes, compared to the cost involved in the production of second-generation metalloporphyrins. (C) 2011 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.apcata.2011.07.019
• 作为产物：
  描述：

  5,10,15,20-tetrakis(3,4-methylenedioxyphenyl)porphyrinogen 在 air 、 硝基苯 、 三乙胺 作用下， 以 溶剂黄146 为溶剂， 反应 1.0h， 生成 5,10,15,20-tetra(2,3-benzo-1,4-dioxa-2-cyclopenten-4'-yl)porphyrin 、 5,10,15,20-tetrakis(3,4-methylenedioxyphenyl)chlorin
  参考文献：
  名称：

  Improved Syntheses of 5,10,15,20-Tetrakisaryl- and Tetrakisalkylporphyrins

  摘要：

  DOI：

  10.3987/com-96-7436

文献信息

• An alternative approach to amino porphyrins
  作者：Shi Weimin、Shen Qi、Wang Yucheng、Lan Lihong、Tao Jingchao

  DOI：10.1002/jhet.410

  日期：——

  HNO3/Cl3CCOOH and one-pot nitration of free tetraarylporphyrins to metalized 2-nitroporphyrin in high yield are described. A novel reducer of Zn/HCOONH4 has been developed for above nitro of porphyrin into amino effectively. J. Heterocyclic Chem., (2010).

  改性硝化四苯基卟啉的苯基在对位用HNO 3 /氯3 CCOOH和一锅硝化的自由tetraarylporphyrins到金属化描述了高产率的2-硝基卟啉。已开发出一种新型的Zn / HCOONH 4还原剂，用于上述的硝基硝基。卟啉有效地转化为氨基。J.杂环化​​学。（2010）。
• Synthesis and Pharmacological Screening of Novel<i>meso</i>-Substituted Porphyrin Analogs
  作者：Ahmed A. Fadda、Rasha E. El-Mekawy、Ahmed I. El-Shafei、Harold Freeman

  DOI：10.1002/ardp.201200313

  日期：2013.1

  novel series of mesotetrakis[aryl]‐21H,23H‐porphyrin derivatives 2a–j was synthesized from the condensation of aldehyde derivatives 1a–j with pyrrole in the presence of p‐toluenesulfonic acid. The synthesized porphyrins were considered as a model to study the free radical‐induced damage of biological membranes and the protective effects of these porphyrins. It was found that these compounds effectively

  在对甲苯磺酸存在下，醛衍生物 1a-j 与吡咯缩合，合成了一系列新型中四[芳基]-21H,23H-卟啉衍生物 2a-j。合成的卟啉被认为是研究自由基诱导的生物膜损伤和这些卟啉的保护作用的模型。发现这些化合物有效抑制自由基诱导的红细胞氧化溶血。带有硫原子、硝基和氯原子的化合物2c和2d表现出比其他类似物显着更高的抗溶血活性。化合物 2a、2c、2d 和 2j 对博莱霉素-铁复合物诱导的 DNA 损伤显示出最高的保护活性。化合物2d、2f、2i和2j被证明具有抗氧化活性。
• Verfahren zur Herstellung von p-Hydroxy-benzaldehyden
  申请人：BAYER AG

  公开号：EP0330036A1

  公开（公告）日：1989-08-30

  p-Hydroxy-benzaldehyde können durch Oxidation der zu­grundeliegenden p-Kresole mit Sauerstoff in Gegenwart basisch reagierender Stoffe in einem Lösungsmittel er­halten werden, wobei zusätzlich in Gegenwart eines Chelatkomplexes von Eisen und/oder Mangan gearbeitet wird. Gegebenenfalls kann in Gegenwart weiterer Metall­salze gearbeitet werden.

  对羟基苯甲醛可以通过在溶剂中存在碱性反应物质的情况下用氧气氧化底层的对甲酚来获得，也可以在存在铁和/或锰的螯合物的情况下进行。如有必要，还可以在有其他金属盐存在的情况下进行。
• Improved method for synthesis of substituted tetraphenylporphins
  作者：A. S. Semeikin、O. I. Koifman、B. D. Berezin

  DOI：10.1007/bf00575244

  日期：1986.6
• Antihypoxic activity of meso-substituted porphyrins
  作者：V. I. Mel'nik、S. É. Sharapova、Z. I. Zhilina、T. V. Stoletova

  DOI：10.1007/bf00764998

  日期：1990.7