ethyl 2-(6-morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetate | 1172993-59-7

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: ethyl 2-(6-morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetate
• CAS: 1172993-59-7
• 化学式: C₂₀H₂₀N₂O₅
• 分子量: 368.389
• InChiKey: VKFKDTNCAJLRCG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.84
• 重原子数：
  27.0
• 可旋转键数：
  4.0
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.35
• 拓扑面积：
  76.15
• 氢给体数：
  0.0
• 氢受体数：
  6.0

反应信息

• 作为反应物：
  描述：

  ethyl 2-(6-morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetate 在 水 、 sodium hydroxide 作用下， 以 甲醇 为溶剂， 反应 24.0h， 以58%的产率得到N-(2'-carboxyacetic acid)-4-morpholino-1,8-naphthalic anhydride
  参考文献：
  名称：

  A simple method for monitoring protein–DNA interactions

  摘要：

  A simple, efficient and cheap method is reported for monitoring interactions between single stranded desoxyribonucleic acids and proteins, using fluorescence spectroscopy and complexes of 5'-dye-DNA conjugates with bovine serum albumin as probes. In the presence of a single stranded DNA-binding protein the complexes with bovine serum albumin are disrupted, which results in a reduction of fluorescence intensity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.167
• 作为产物：
  描述：

  吗啉 、 N-ethoxycarbonylmethyl-4-bromo-1,8-naphthalimide 在 三乙胺 作用下， 以 N-甲基吡咯烷酮 为溶剂， 反应 2.0h， 以67%的产率得到ethyl 2-(6-morpholino-1,3-dioxo-1H-benzo[de]isoquinolin-2(3H)-yl)acetate
  参考文献：
  名称：

  A simple method for monitoring protein–DNA interactions

  摘要：

  A simple, efficient and cheap method is reported for monitoring interactions between single stranded desoxyribonucleic acids and proteins, using fluorescence spectroscopy and complexes of 5'-dye-DNA conjugates with bovine serum albumin as probes. In the presence of a single stranded DNA-binding protein the complexes with bovine serum albumin are disrupted, which results in a reduction of fluorescence intensity. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.03.167