methyl 2,2-bis(4-aminophenyl)acetate | 119114-18-0

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: methyl 2,2-bis(4-aminophenyl)acetate
• 英文别名: bis-(4-amino-phenyl)-acetic acid methyl ester；Bis-(4-amino-phenyl)-essigsaeure-methylester
• CAS: 119114-18-0
• 化学式: C₁₅H₁₆N₂O₂
• 分子量: 256.304
• InChiKey: AETVRBOLABZSEM-UHFFFAOYSA-N

物化性质

• 沸点：
  252-258 °C(Press: 1.5 Torr)
• 密度：
  1.216±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.16
• 重原子数：
  19.0
• 可旋转键数：
  3.0
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.13
• 拓扑面积：
  78.34
• 氢给体数：
  2.0
• 氢受体数：
  4.0

反应信息

• 作为反应物：
  描述：

  methyl 2,2-bis(4-aminophenyl)acetate 在 溶剂黄146 作用下， 生成 bis-(4-amino-phenyl)-acetic acid
  参考文献：
  名称：

  4,4′-Diaminodiphenylacetic Acid

  摘要：

  DOI：

  10.1021/ja01175a506
• 作为产物：
  描述：

  methyl 2,2-bis(4-nitrophenyl)ethanoate 在 1% Pd/C 、 氢气 作用下， 生成 methyl 2,2-bis(4-aminophenyl)acetate
  参考文献：
  名称：

  Diphenylmethylene hydroxamic acids as selective class IIa histone deacetylase inhibitors

  摘要：

  We have identified a series of diphenylmethylene hydroxamic acids as novel and selective HDAC class IIa inhibitors. The original hit, N-hydroxy-2,2-diphenylacetamide (6), has sub-micromolar class IIa HDAC inhibitory activity, while the rigidified oxygen analogue, N-hydroxy-9H-xanthene-9-carboxamide (13), is slightly more selective for HDAC7 with an IC50 of 0.05 mu M. Substitution of 6 allows for the modulation of selectivity and potency amongst the class IIa HDAC isotypes. (C) 2009 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2009.08.010

文献信息

• Lewis-Acid-Catalyzed Selective Friedel–Crafts Reaction or Annulation between Anilines and Glyoxylates
  作者：Wangyu Li、Dungai Wang、Xiao Liang、Zhixiong Jin、Shiwen Zhou、Guanru Chen、Yuanjiang Pan

  DOI：10.1021/acs.orglett.2c01115

  日期：2022.4.29

  A Lewis-acid-catalyzed selective reaction between anilines and glyoxylates was developed for synthesis of diarylmethanes or oxoimidazolidines. Under the catalysis of AgOTf, a series of anilines-based diarylmethanes, including primary, secondary, and tertiary anilines, were obtained in moderate to good yields. Moreover, stereoselective oxoimidazolidines were performed with the catalysis of Cu(OAc)2·H2O

  开发了苯胺和乙醛酸盐之间的路易斯酸催化选择性反应，用于合成二芳基甲烷或氧代咪唑烷。在AgOTf的催化下，以中等至良好的收率获得了一系列基于苯胺的二芳基甲烷，包括伯苯胺、仲苯胺和叔苯胺。此外，在Cu(OAc) 2 ·H 2 O的催化下，进行了立体选择性氧代咪唑烷的制备。
• He, Yun; Zhao, He; Pan, Xinfu, Synthetic Communications, 1989, vol. 19, # 17, p. 3047 - 3050
  作者：He, Yun、Zhao, He、Pan, Xinfu、Wang, Shaofei

  DOI：——

  日期：——
• HE, YUN;ZHAO, HE;PAN, XINFU;WANG, SHAOFEI, SYNTH. COMMUN., 19,(1989) N7, C. 3047-3050
  作者：HE, YUN、ZHAO, HE、PAN, XINFU、WANG, SHAOFEI

  DOI：——

  日期：——