4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine | 914612-34-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶并嘧啶类
• 英文名称: 4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine
• 英文别名: 4-chloro-6-(5-methylpyridin-2-yl)-7,8-dihydro-5H-pyrido[4,3-d]pyrimidine
• CAS: 914612-34-3
• 化学式: C₁₃H₁₃ClN₄
• 分子量: 260.726
• InChiKey: LRJANZYRGCLJOT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.5
• 重原子数：
  18
• 可旋转键数：
  1
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.31
• 拓扑面积：
  41.9
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  2-甲基苯甲基胺 、 4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine 在 N,N-二异丙基乙胺 作用下， 以 乙腈 为溶剂， 反应 0.25h， 生成 (2-Methyl-benzyl)-[6-(5-methyl-pyridin-2-yl)-5,6,7,8-tetrahydro-pyrido[4,3-d]pyrimidin-4-yl]-amine
  参考文献：
  名称：

  Fused heterocyclic compounds, and compositions and uses thereof

  摘要：

  披露了具有以下式1的融合杂环化合物：其中A、B、L、N、R1、R3、R4'、Y和Z的定义如本文所述。该化合物及其药物组成物对哺乳动物包括人类的各种疾病的预防和治疗是有用的，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。

  公开号：

  US20060258689A1
• 作为产物：
  描述：

  6-苄基-5,6,7,8-四氢吡啶并[4,3-d]嘧啶-4(3H)-酮 在 palladium(II) hydroxide N,N-二甲基苯胺 、 三乙胺 、 N,N-二异丙基乙胺 、 三氯氧磷 作用下， 以 1,4-二氧六环 、 甲醇 、 N,N-二甲基乙酰胺 、 1,2-二氯乙烷 为溶剂， 反应 9.0h， 生成 4-chloro-5,6,7,8-tetrahydro-6-(5-methylpyridin-2-yl)pyrido[4,3-d]pyrimidine
  参考文献：
  名称：

  WO2008/123963

  摘要：

  公开号：

文献信息

• Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds and compositions thereof useful in the treatment of conditions associated with neurological and inflammatory disorders and dysfunctions
  申请人：Renovis, Inc.

  公开号：US07745451B2

  公开（公告）日：2010-06-29

  Fused heterocyclic compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  公开了具有式1的融合杂环化合物：其中A、B、L、N、R1、R3、R4'、Y和Z的定义如本文所述。这些化合物及其制药组合物对于哺乳动物，包括人类的各种疾病的预防和治疗有用，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• Pyrid-2yl fused heterocyclic compounds, and compositions and uses thereof
  申请人：Wei Zhi-Liang

  公开号：US08653091B2

  公开（公告）日：2014-02-18

  Fused heterocyclic compounds are provided according to formula 1a or 1b: where R1, R2, and R3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1a或1b提供的融合杂环化合物：其中R1、R2和R3如本文所定义。所提供的化合物及其制药组合物对于哺乳动物，包括人类的预防和治疗各种疾病是有用的，包括但不限于疼痛，炎症，认知障碍，焦虑，抑郁等。
• Tetrahydronaphthyridine and tetrahydropyrido[4,3-D]pyrimidine compounds and compositions thereof useful for the treatment of inflammatory and respiratory diseases
  申请人：Kelly Michael G.

  公开号：US08859545B2

  公开（公告）日：2014-10-14

  Tetrahydronaphthyridine and tetrahydropyrido[4,3-d]pyrimidine compounds are disclosed that have formula 1: where A, B, L, N, R1, R3, R4′, Y and Z are as defined herein. The compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, respiratory conditions, and others.

  本文揭示了具有1式的四氢萘啶和四氢吡咯[4,3-d]嘧啶化合物，其中A、B、L、N、R1、R3、R4'、Y和Z如本文所定义。这些化合物及其制药组合物对哺乳动物包括人类的各种疾病的预防和治疗有用，例如但不限于疼痛、炎症、呼吸道疾病等。
• PYRID-2YL FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF
  申请人：Wei Zhi-Liang

  公开号：US20110009432A1

  公开（公告）日：2011-01-13

  Fused heterocyclic compounds are provided according to formula 1a or 1b: where R 1 , R 2 , and R 3 are as defined herein. Provided compounds and pharmaceutical compositions thereof are useful for the prevention and treatment of a variety of conditions in mammals including humans, including by way of non-limiting example, pain, inflammation, cognitive disorders, anxiety, depression, and others.

  提供了按照公式1a或1b定义的熔合杂环化合物：其中R1、R2和R3如本文所定义。所提供的化合物及其制剂在哺乳动物中包括人类的预防和治疗各种病症，包括但不限于疼痛、炎症、认知障碍、焦虑、抑郁等。
• FUSED HETEROCYCLIC COMPOUNDS, AND COMPOSITIONS AND USES THEREOF
  申请人：Renovis, Inc.

  公开号：EP1885369A2

  公开（公告）日：2008-02-13