Chloromethyl olanzapinium | 735264-27-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯二氮卓类
• 英文名称: Chloromethyl olanzapinium
• 英文别名: 4-[4-(chloromethyl)-4-methylpiperazin-4-ium-1-yl]-2-methyl-10H-thieno[2,3-b][1,5]benzodiazepine
• CAS: 735264-27-4
• 化学式: C18H22ClN4S+
• 分子量: 361.9
• InChiKey: FQYHAAZWAYLVAQ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.6
• 重原子数：
  24
• 可旋转键数：
  2
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.39
• 拓扑面积：
  55.9
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• A pharmaceutical formulation containing olanzapine
  申请人：Actavis Group PTC ehf.

  公开号：EP2343058A2

  公开（公告）日：2011-07-13

  This invention relates to a stable pharmaceutical formulation containing olanzapine. The composition comprises olanzapine or a pharmaceutically acceptable salt thereof, one or more suitable pharmaceutical excipients and a compound of formula I and/or a compound of formula II: or a pharmaceutically acceptable salt thereof.

  本发明涉及一种含有奥氮平的稳定药物制剂。该组合物包含奥氮平或其药学上可接受的盐、一种或多种合适的药用辅料以及式 I 化合物和/或式 II 化合物： 或其药学上可接受的盐。
• Process for removing impurity S from olanzapine polymorphic form I
  申请人：Adamed SP. Z O.O.

  公开号：EP1581537B1

  公开（公告）日：2007-11-21
• STABLE COMPOSITION FOR A PHARMACEUTICAL FORMULATION CONTAINING OLANZAPINE
  申请人：Actavis Group PTC EHF

  公开号：EP1951205A2

  公开（公告）日：2008-08-06
• Process For Making Form I Of Olanzapine
  申请人：Thakashinamoorthy Chandiran

  公开号：US20080009481A1

  公开（公告）日：2008-01-10

  This invention discloses a new dihydrate polymorph of Olanzapine (hereinafter referred to as “dihydrate C”), and process for recovering anhydrous Form I of Olanzapine from this novel Dihydrate C.
• Pharmaceutical Formulation
  申请人：Stefansson Stefan Einar

  公开号：US20090221560A1

  公开（公告）日：2009-09-03

  This invention relates to a stable pharmaceutical formulation containing olanzapine. The composition comprises olanzapine or a pharmaceutically acceptable salt thereof, one or more suitable pharmaceutical excipients and a compound of formula (I) and/or a compound of formula (II): or a pharmaceutically acceptable salt thereof.