1,1'-(1,6-hexanediyl)bis(2,5-pyrrolidinedione) | 13030-16-5

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,1'-(1,6-hexanediyl)bis(2,5-pyrrolidinedione)
• 英文别名: 1-[6-(2,5-dioxopyrrolidin-1-yl)hexyl]pyrrolidine-2,5-dione
• CAS: 13030-16-5
• 化学式: C₁₄H₂₀N₂O₄
• 分子量: 280.324
• InChiKey: PBFKSBAPGGMKKJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.5
• 重原子数：
  20
• 可旋转键数：
  7
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.71
• 拓扑面积：
  74.8
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为反应物：
  描述：

  1,1'-(1,6-hexanediyl)bis(2,5-pyrrolidinedione) 、 乙二胺 以 乙醇 为溶剂， 生成 hexamethylenedisuccinamidoethylenediamine
  参考文献：
  名称：

  The synthesis of alkylene and arylene amidodiamines

  摘要：

  DOI：

  10.1007/bf00852694
• 作为产物：
  描述：

  丁二酰亚胺 、 1,6-二溴己烷 在 sodium hydride 作用下， 生成 1,1'-(1,6-hexanediyl)bis(2,5-pyrrolidinedione)
  参考文献：
  名称：

  Chemical differentiating agents. Differentiation of HL-60 cells by hexamethylenebis[acetamide]analogs

  摘要：

  Hexamethylenebis[acetamide] (HMBA) is an agent in clinical trial that induces differentiation of certain types of tumor cells to nonmalignant phenotypes. In an attempt to discover a more potent compound, a number of bis-functionalized amides, imides, and hydrazine derivatives of HMBA were prepared and evaluated in vitro with the HL-60 human promyelocytic leukemia cell line. Among the compounds evaluated, the 5,5-dimethylhydantoin derivative is almost 10 times more potent than HMBA in inducing differentiation. The bis-imide, diacetyl-HMBA, is both more potent and effective than its parent compound. Six of the 16 compounds evaluated cause at least 20% differentiation. An inverse relationship between the degree of differentiation and the percentage of viable cells is described for HMBA and its analogues.

  DOI：

  10.1021/jm00385a025

文献信息

• [EN] SUBSTITUTED 2-BENZYLIDENE-2H-BENZO[b][1,4]THIAZIN-3(4H)-ONES, DERIVATIVES THEREOF, AND THERAPEUTIC USES THEREOF<br/>[FR] 2-BENZYLIDÈNE-2H-BENZO[B][1,4]THIAZIN-3(4H)-ONES SUBSTITUÉES, DÉRIVÉS DE CELLES-CI, ET LEURS UTILISATIONS THÉRAPEUTIQUES
  申请人：UNIV TEMPLE

  公开号：WO2012166586A1

  公开（公告）日：2012-12-06

  The present invention relates to compounds according to Formula I and salts thereof, wherein R1, R2, R3, R4, Ar, and n are as defined herein. Methods for preparing compounds of Formula I are also provided. The present invention further includes methods of treating cellular proliferative disorders, such as cancer, with the compounds of Formula I.

  本发明涉及根据公式I的化合物及其盐，其中R1、R2、R3、R4、Ar和n如本文所述定义。还提供了制备公式I化合物的方法。本发明进一步包括使用公式I的化合物治疗细胞增殖障碍的方法，例如癌症。
• [EN] SUBSTITUTED PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES AND THERAPEUTIC USES THEREOF<br/>[FR] PYRIDO[2,3-D]PYRIMIDIN-7(8H)-ONES SUBSTITUÉS ET LEURS UTILISATIONS THÉRAPEUTHIQUES
  申请人：UNIV TEMPLE

  公开号：WO2011075616A1

  公开（公告）日：2011-06-23

  Compounds useful as antiproliferative agents according to Formula (I), wherein n, A, R1, R2, and Ar1 are as defined herein, and salts thereof; antibody conjugates, pharmaceutical compositions, methods of treatment, and synthetic methods are provided.

  根据本文件所述的公式(I)，有用的作为抗增殖剂的化合物，其中n、A、R1、R2和Ar1定义如文中所述，以及它们的盐；提供了抗体偶联物、药物组合物、治疗方法以及合成方法。
• Synthesis of Cyclic Imides by Acceptorless Dehydrogenative Coupling of Diols and Amines Catalyzed by a Manganese Pincer Complex
  作者：Noel Angel Espinosa-Jalapa、Amit Kumar、Gregory Leitus、Yael Diskin-Posner、David Milstein

  DOI：10.1021/jacs.7b08341

  日期：2017.8.30

  base-metal-catalyzed dehydrogenative coupling of diols and amines to form cyclic imides is reported. The reaction is catalyzed by a pincer complex of the earth abundant manganese and forms hydrogen gas as the sole byproduct, making the overall process atom economical and environmentally benign.

  报告了碱金属催化的二醇和胺脱氢偶联形成环状酰亚胺的第一个例子。该反应由地球上丰富的锰的钳形络合物催化，并形成氢气作为唯一的副产品，使整个过程原子经济且环保。
• PROCESSES FOR PREPARING (E)-STYRYLBENZYLSULFONE COMPOUNDS AND USES THEREOF FOR TREATING PROLIFERATIVE DISORDERS
  申请人：SIRIGIREDDY REDDY

  公开号：US20100152491A1

  公开（公告）日：2010-06-17

  Processes for preparing (E)-2,4,6-(Trimethoxystyryl)-3-O-Phosphate Disodium-4-Methoxybenzyl Sulfones and uses thereof as antiproliferative agents, including, for example, anticancer agents, and as radioprotective and chemoprotective agents.

  制备(E)-2,4,6-(三甲氧基苯乙烯基)-3-O-磷酸二钠-4-甲氧基苯甲基磺酮的方法及其作为抗增殖剂的用途，包括作为抗癌剂，以及作为放射保护和化学保护剂的用途。
• Preparation, characterization and copolymerization of the 12-membered cyclic diamide 1,6-diazacyclododecane-2,5-dione
  作者：Ethem Kaya、Eylem Tarkin-Tas、Scott Osborn、Roger Ayotte、Steven Manning、Lon J. Mathias

  DOI：10.1002/pola.26975

  日期：2014.1.1

  in the formation of two different cyclic amides, which were fully analyzed by 1H and 13C solution nuclear magnetic resonance spectrometry and mass spectrometry. Copolymerization of cyclic amides with ε‐caprolactam via an anionic route gave a block copolyamide with a two distinct endotherms in the differential scanning calorimetry analysis. However, copolymerization by the hydrolytic route gave only

  以相当高的收率（〜45％）成功合成了尼龙64的12元环状二酰胺单体。改变合成条件以观察二胺和琥珀酰氯反应物对产率的影响。三倍过量的1,6-六亚甲基二胺（HDA）可获得最高的收率，而进一步增加HDA的量则会降低收率。使用N，N-二异丙基乙胺作为除酸剂导致形成了两种不同的环酰胺，并通过1 H和13进行了全面分析C溶液核磁共振波谱法和质谱法。在差示扫描量热分析中，环状酰胺与ε-己内酰胺通过阴离子途径共聚得到具有两个不同吸热峰的嵌段共聚酰胺。然而，通过水解途径的共聚仅得到具有末端64个单元的尼龙6。©2013 Wiley Periodicals，Inc. J. Polym。科学，A部分：Polym。化学 2014，52，96-103