| 1452864-73-1

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 苯并咪唑类
• CAS: 1452864-73-1
• 化学式: C₁₆H₂₀N₄O
• 分子量: 284.361
• InChiKey: UBICNGPBLDVDFB-HAQNSBGRSA-N

反应信息

• 作为产物：
  描述：

  、 4-chloro-1,2-dihydroimidazo[1,2-a]quinoxaline 以 二甲基亚砜 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Hit-to-lead optimization and kinase selectivity of imidazo[1,2-a]quinoxalin-4-amine derived JNK1 inhibitors

  摘要：

  As the result of a rhJNK1 HTS, the imidazo[1,2-a]quinoxaline 1 was identified as a 1.6 mu M rhJNK1 inhibitor. Optimization of this compound lead to AX13587 (rhJNK1 IC50 = 160 nM) which was co-crystallized with JNK1 to identify key molecular interactions. Kinase profiling against 125+ kinases revealed AX13587 was an inhibitor of JNK, MAST3, and MAST4 whereas its methylene homolog AX14373 (native JNK1 IC50 = 47 nM) was a highly specific JNK inhibitor. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.bmcl.2013.06.087