(2R)-2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-ethyl ester | 226255-32-9

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2R)-2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-ethyl ester
• 英文别名: tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-ethyl ester；1-O-benzyl 6-O-ethyl (2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-4-oxohexanedioate
• CAS: 226255-32-9
• 化学式: C₂₀H₂₇NO₇
• 分子量: 393.437
• InChiKey: QMFIAXPHJVQYIX-MRXNPFEDSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  28
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  108
• 氢给体数：
  1
• 氢受体数：
  7

反应信息

• 作为反应物：
  描述：

  (2R)-2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-ethyl ester 在 吡啶 、 羟胺 、 三乙胺 作用下， 以 四氯化碳 为溶剂， 生成 ethyl (4aS,6R,7S,8S,8aR)-4-(4-methylphenyl)sulfonyl-3-[(2R)-2-[(2-methylpropan-2-yl)oxycarbonylamino]-3-oxo-3-phenylmethoxypropyl]-7,8-bis(phenylmethoxy)-6-(phenylmethoxymethyl)-6,7,8,8a-tetrahydro-4aH-pyrano[3,2-b][1,4]thiazine-2-carboxylate
  参考文献：
  名称：

  Glycosyl Transfer to Nitrogen via Cycloaddition

  摘要：

  [GRAPHICS]This letter describes the reduction to practice of a novel concept for functionalization of the anomeric carbon of carbohydrates with a nitrogen substituent. Thus, bisheterodienes with a thiono sulfur terminus and a sulfonylimine terminus are shown to undergo cycloaddition smoothly and stereoselectively to three different glycals.

  DOI：

  10.1021/ol990583l
• 作为产物：
  描述：

  N-叔丁氧羰基-D-天冬氨酸 1-苄酯 在 4-二甲氨基吡啶 、 异丙烯基氯甲酸酯 、 三乙胺 作用下， 生成 (2R)-2-tert-butoxycarbonylamino-4-oxo-hexanedioic acid 1-benzyl ester 6-ethyl ester
  参考文献：
  名称：

  Glycosyl Transfer to Nitrogen via Cycloaddition

  摘要：

  [GRAPHICS]This letter describes the reduction to practice of a novel concept for functionalization of the anomeric carbon of carbohydrates with a nitrogen substituent. Thus, bisheterodienes with a thiono sulfur terminus and a sulfonylimine terminus are shown to undergo cycloaddition smoothly and stereoselectively to three different glycals.

  DOI：

  10.1021/ol990583l

文献信息

• A method for manufacturing optically active coumaryl amino acid salts and the coumaryl aminoacid salts thus obtained
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1559712A1

  公开（公告）日：2005-08-03

  The present invention relates to the field of the synthesis of optically active amino acids, mainly for the purpose of manufacturing optically active polypeptides that are useful as labelled detection tools. The manufacturing method involves the preparation of optically active coumaryl amino acid salts of formula (I).

  本发明涉及光学活性氨基酸合成领域，主要用于制造作为标记检测工具有用的光学活性多肽。该制造方法涉及制备式(I)的光学活性香豆素氨基酸盐。
• Method for manufacturing optically pure coumaryl amino acids and the novel coumaryl aminoacids thus obtained
  申请人：Garbay Christiane

  公开号：US20070161807A1

  公开（公告）日：2007-07-12

  The present invention relates to the field of the synthesis of optically pure amino acid derivatives, mainly for the purpose of manufacturing optically active polypeptides that are useful as labelled detection tools.

  本发明涉及合成光学纯氨基酸衍生物的领域，主要用于制造作为标记检测工具有用的光学活性多肽。
• A Very Short Route to Enantiomerically Pure Coumarin-Bearing Fluorescent Amino Acids
  作者：Marie-Priscille Brun、Laurent Bischoff、Christiane Garbay

  DOI：10.1002/anie.200454116

  日期：2004.6.28
• A METHOD FOR MANUFACTURING OPTICALLY PURE COUMARYL AMINO ACID SALTS AND THE COUMARYL AMINO ACID SALTS THUS OBTAINED
  申请人：INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM)

  公开号：EP1711483A2

  公开（公告）日：2006-10-18
• [EN] A METHOD FOR MANUFACTURING OPTICALLY PURE COUMARYL AMINO ACIDS AND THE NOVEL COUMARYL AMINOACIDS THUS OBTAINED<br/>[FR] PROCEDE DE FABRICATION D'ACIDES AMINES DE COUMARYLE OPTIQUEMENT PURS ET NOUVEAUX ACIDES AMINES DE COUMARYLE AINSI OBTENUS
  申请人：INST NAT RECH MEDICALE INSERM

  公开号：WO2005075448A2

  公开（公告）日：2005-08-18

  The present invention relates to the field of the synthesis of optically pure amino acid derivatives, mainly for the purpose of manufacturing optically active polypeptides that are useful as labeled detection tools.