N-ethoxycarbonyl-3,4,5,6-tetrahydrophthalimide | 55533-35-2

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 异吲哚及其衍生物
• 英文名称: N-ethoxycarbonyl-3,4,5,6-tetrahydrophthalimide
• 英文别名: 1,3-dioxo-1,3,4,5,6,7-hexahydro-isoindole-2-carboxylic acid ethyl ester；N-Carbethoxy-3,4,5,6-tetrahydrophthalimid；N-ethoxycarbonyl-3,4,5,6-tetrahydrophtalimide；ethyl 1,3-dioxo-4,5,6,7-tetrahydroisoindole-2-carboxylate
• CAS: 55533-35-2
• 化学式: C₁₁H₁₃NO₄
• 分子量: 223.229
• InChiKey: UVPIEFRWDOQUBD-UHFFFAOYSA-N

物化性质

• 沸点：
  346.7±25.0 °C(Predicted)
• 密度：
  1.31±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.55
• 拓扑面积：
  63.7
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  3,4,5,6-四氢邻苯二甲酰亚胺 、 氯甲酸乙酯 在 三乙胺 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 4.0h， 以42%的产率得到N-ethoxycarbonyl-3,4,5,6-tetrahydrophthalimide
  参考文献：
  名称：

  Inactivation method

  摘要：

  本发明涉及热稳定酶领域，其失活方法以及相关用途、试剂盒和试剂。具体而言，本发明涉及一种在水性或非水性条件下通过化学修饰可逆失活嗜热酶的方法。

  公开号：

  US09273304B2

文献信息

• REVERSIBLY INACTIVATED THERMOSTABLE REVERSE TRANSCRIPTASES, COMPOSITIONS AND METHODS FOR USE
  申请人：Life Technologies Corporation

  公开号：EP3186374A1

  公开（公告）日：2017-07-05
• Inactivation Method
  申请人：Thermo Fisher Scientific Baltics UAB

  公开号：US20170114339A1

  公开（公告）日：2017-04-27

  The present invention relates to the field of thermostable enzymes, methods for their inactivation, and related uses, kits and reagents. In particular, the invention relates to a method for reversible inactivation of thermophilic enzymes by chemical modification under aqueous or non-aqueous conditions.
• US9273304B2
  申请人：——

  公开号：US9273304B2

  公开（公告）日：2016-03-01
• [EN] REVERSIBLY INACTIVATED THERMOSTABLE REVERSE TRANSCRIPTASES, COMPOSITIONS AND METHODS FOR USE<br/>[FR] TRANSCRIPTASES INVERSES THERMOSTABLES INACTIVÉES DE MANIÈRE RÉVERSIBLE, COMPOSITIONS ET MÉTHODES D'UTILISATION
  申请人：LIFE TECHNOLOGIES CORP

  公开号：WO2016033116A1

  公开（公告）日：2016-03-03

  The present invention provides reversibly inactivated reverse transcriptase enzymes, particularly those having increased thermostability and/or thermoreactivity and compositions, methods and kits that include such enzymes, for the reverse transcription of nucleic acid molecules. Also provided are compositions and methods for the reactivation of reversibly inactivated reverse transcriptases. More particularly, the present invention relates to compositions and methods that can increase the speed of reactivation and stabilize reactivation of chemically modified reverse transcriptase enzymes prior to, or as part of a reverse transcription reaction. As compared to existing compositions and methods, the reversibly inactivated reverse transcriptase enzymes of the present invention provide for a significant reduction in non-specific reverse transcription from template nucleic acid molecules.
• Inactivation method
  申请人：Fermentas UAB

  公开号：EP1806400B1

  公开（公告）日：2013-03-13