propargyl-11-bromoundecanoate | 26755-61-3

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: propargyl-11-bromoundecanoate
• 英文别名: Prop-2-ynyl 11-bromoundecanoate
• CAS: 26755-61-3
• 化学式: C₁₄H₂₃BrO₂
• 分子量: 303.239
• InChiKey: BDZXFXMAYXAKAJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.7
• 重原子数：
  17
• 可旋转键数：
  12
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.79
• 拓扑面积：
  26.3
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为反应物：
  描述：

  1,1,2-三甲基苯-1H-苯并[e]吲哚 、 propargyl-11-bromoundecanoate 在 吡啶 作用下， 反应 3.5h， 生成 3,3′-di-(10-propargyloxycarbonyldecyl)-1,1,1′,1′-tetramethyl-1H-dibenzo[e]indocarbocyanine bromide
  参考文献：
  名称：

  Cyanine Dyes as Optical Contrast Agents for Ophthalmological Surgery

  摘要：

  Cyanine dyes were prepared as optical contrast media for supporting the surgery of the lamina limitans interna (LLI) of the retina and other structures of the human eye. Their absorption spectra were adapted both to the spectral sensitivity of the human eye and to standard illumination. The contrast could be further amplified by the application of the strong fluorescence of the dyes used. The binding of the dyes to various surfaces was studied. No toxic effects could be detected for the applied dyes.

  DOI：

  10.1021/jm2001986

文献信息

• Scalable synthesis of sequence-defined, unimolecular macromolecules by Flow-IEG
  作者：Frank A. Leibfarth、Jeremiah A. Johnson、Timothy F. Jamison

  DOI：10.1073/pnas.1508599112

  日期：2015.8.25

  We report a semiautomated synthesis of sequence and architecturally defined, unimolecular macromolecules through a marriage of multistep flow synthesis and iterative exponential growth (Flow-IEG). The Flow-IEG system performs three reactions and an in-line purification in a total residence time of under 10 min, effectively doubling the molecular weight of an...

  我们报告了多步流合成与迭代指数增长（Flow-IEG）结合起来的半自动合成序列和结构上定义的单分子大分子。Flow-IEG系统可在不到10分钟的总停留时间内执行三个反应并进行在线纯化，从而有效地使...的分子量增加了一倍。
• NAPHTHOCYANINE ALS KONTRASTMITTEL
  申请人：PHARMPUR GmbH

  公开号：EP2576699B1

  公开（公告）日：2017-07-12