(S)-2-(3-mercaptopropyl)pentanedioic acid | 848952-63-6

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (S)-2-(3-mercaptopropyl)pentanedioic acid
• 英文别名: (2S)-2-(3-sulfanylpropyl)pentanedioic acid
• CAS: 848952-63-6
• 化学式: C₈H₁₄O₄S
• 分子量: 206.263
• InChiKey: FNLNSQHJKVQCBP-ZCFIWIBFSA-N

物化性质

• 沸点：
  377.1±32.0 °C(Predicted)
• 密度：
  1?+-.0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  13
• 可旋转键数：
  7
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  75.6
• 氢给体数：
  3
• 氢受体数：
  5

反应信息

• 作为产物：
  描述：

  (S)-2-[3-((S)-4,6-Dicarboxy-hexyldisulfanyl)-propyl]-pentanedioic acid 在 tris(carboxyethyl)phosphine hydrochloride 、 碳酸氢钠 作用下， 反应 0.03h， 生成 (S)-2-(3-mercaptopropyl)pentanedioic acid
  参考文献：
  名称：

  谷氨酸羧肽酶II抑制的对映体特异性。

  摘要：

  以高光学纯度（> 97％ee）合成了两种代表性的谷氨酸羧肽酶II（GCP II）抑制剂2-（羟基五氟苯基甲基-膦酰基甲基）戊二酸2和2-（3-巯基丙基）戊二酸3。2的两个对映异构体是由先前报道的手性中间体（R）-和（S）-2-（羟基膦酰基甲基）戊二酸苄酯8制备的。（R）-和（S）-3的合成涉及水解（R）-和（S）-3-（2-氧代-四氢-硫吡喃-3-基）丙酸，（R）-和（S）-11，通过手性色谱分离得到的相应的光学纯硫内酯外消旋体11. GCP II抑制试验表明，（S）-2的效力比（R）-2高40倍。相反，两种3的对映体均以几乎相同的效力抑制GCP II。

  DOI：

  10.1021/jm049258g

文献信息

• [EN] DIAGNOSTIC DEVICE FOR THE DETECTION OF DISEASE RELATED TARGET STRUCTURES<br/>[FR] DISPOSITIF DIAGNOSTIQUE POUR LA DÉTECTION DE STRUCTURES CIBLES ASSOCIÉES À UNE MALADIE
  申请人：GILUPI GMBH

  公开号：WO2015028489A1

  公开（公告）日：2015-03-05

  The present invention provides a diagnostic device allowing highly specific and efficient in vivo and/or in vitro detection of a bio marker in a broad range of bodily fluids or tissues. The diagnostic device is composed of a binding agent that specifically binds a bio marker present in the bodily fluid linked by a linker compound or layer to the substrate, which includes a metallic, a semiconductor, or a polymeric carrier. The present invention further provides methods using said device for the detection of bio markers, as well as kits comprising said device and suitable ingredients for the detections of bio markers in a bodily fluid. Furthermore, the invention provides suitable in vivo and in vitro applications of said binding agent for the detection of specific disease-related target structures.

  本发明提供了一种诊断设备，允许在广泛范围的体液或组织中高度特异和高效地体内和/或体外检测生物标志物。该诊断设备由一个结合剂组成，该结合剂特异性地结合存在于体液中的生物标志物，通过连接剂化合物或层连接到基底上，该基底包括金属、半导体或聚合物载体。本发明还提供了使用该设备进行生物标志物检测的方法，以及包括该设备和适用于体液中生物标志物检测的合适成分的试剂盒。此外，该发明提供了适用于检测特定与疾病相关的靶标结构的结合剂的体内和体外应用。
• Diagnostic device for the detection of disease related target structures
  申请人：GILUPI GmbH

  公开号：EP2842578A1

  公开（公告）日：2015-03-04

  The present invention provides a diagnostic device allowing highly specific and efficient in vivo and/or in vitro detection of a bio marker in a broad range of bodily fluids or tissues. The diagnostic device is composed of a binding agent that specifically binds a bio marker present in the bodily fluid linked by a linker compound or layer to the substrate, which includes a metallic, a semiconductor, or a polymeric carrier. The present invention further provides methods using said device for the detection of bio markers, as well as kits comprising said device and suitable ingredients for the detections of bio markers in a bodily fluid. Furthermore, the invention provides suitable in vivo and in vitro applications of said binding agent for the detection of specific disease-related target structures.

  本发明提供了一种诊断装置，可在体内和/或体外高度特异、高效地检测各种体液或组织中的生物标记物。该诊断装置由一种结合剂组成，该结合剂可特异性地结合存在于体液中的生物标记物，并通过连接化合物或连接层与基底相连，基底包括金属、半导体或聚合物载体。本发明进一步提供了使用所述装置检测生物标记物的方法，以及包含所述装置和用于检测体液中生物标记物的适当成分的试剂盒。此外，本发明还提供了所述结合剂在体内和体外检测特定疾病相关目标结构的合适应用。
• DIAGNOSTIC DEVICE FOR THE DETECTION OF BIOMARKERS
  申请人：GILUPI GmbH

  公开号：EP2842578B1

  公开（公告）日：2018-06-27
• Diagnostic Device for the Detection of Disease Related Target Structures
  申请人：GILUPI GMBH

  公开号：US20160216257A1

  公开（公告）日：2016-07-28

  The present invention provides a diagnostic device allowing highly specific and efficient in vivo and/or in vitro detection of a bio marker in a broad range of bodily fluids or tissues. The diagnostic device is composed of a binding agent that specifically binds a bio marker present in the bodily fluid linked by a linker compound or layer to the substrate, which includes a metallic, a semiconductor, or a polymeric carrier. The present invention further provides methods using said device for the detection of bio markers, as well as kits comprising said device and suitable ingredients for the detections of bio markers in a bodily fluid. Furthermore, the invention provides suitable in vivo and in vitro applications of said binding agent for the detection of specific disease-related target structures.