4-Acetoxy-3-benzylsulfanyl-2-benzylsulfanylmethyl-5-oxo-2,5-dihydro-furan-2-carboxylic acid ethyl ester | 657411-32-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二氢呋喃
• 英文名称: 4-Acetoxy-3-benzylsulfanyl-2-benzylsulfanylmethyl-5-oxo-2,5-dihydro-furan-2-carboxylic acid ethyl ester
• 英文别名: Ethyl 4-acetyloxy-3-benzylsulfanyl-2-(benzylsulfanylmethyl)-5-oxofuran-2-carboxylate
• CAS: 657411-32-0
• 化学式: C₂₄H₂₄O₆S₂
• 分子量: 472.583
• InChiKey: UPMYHGIZGXWFDI-UHFFFAOYSA-N

物化性质

• 沸点：
  626.2±55.0 °C(Predicted)
• 密度：
  1.32±0.1 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  4.4
• 重原子数：
  32
• 可旋转键数：
  12
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.29
• 拓扑面积：
  130
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• Furanone derivatives
  申请人：——

  公开号：US20040029812A1

  公开（公告）日：2004-02-12

  The invention relates to a method of treating with furanone derivatives and the phmaceutically acceptable salts therof, one or more conditions of the skin, in particular regulating skin condition, regulating signs of skin aging, treating a number of conditions suchas contact dermatitis, skin irritation, rosacea, acne, psoriasis, and preventing and protecting skin tissue against age-related damage or damage resulting from insults such as harmful (UV) radiation or environmental pollution, stress and fatigue.

  该发明涉及一种利用呋喃酮衍生物及其药用盐治疗皮肤的方法，特别是调节皮肤状况，调节皮肤衰老迹象，治疗诸如接触性皮炎、皮肤刺激、酒渣鼻、痤疮、牛皮癣等多种疾病，以及预防和保护皮肤组织免受与年龄相关的损伤或因有害（紫外线）辐射、环境污染、压力和疲劳等因素导致的损害。
• FURANONE DERIVATIVES
  申请人：Galileo Pharmaceuticals, Inc.

  公开号：EP1660080A1

  公开（公告）日：2006-05-31
• US7985771B2
  申请人：——

  公开号：US7985771B2

  公开（公告）日：2011-07-26
• [EN] FURANONE DERIVATIVES<br/>[FR] DERIVES DE FURANONE
  申请人：GALILEO PHARMACEUTICALS INC

  公开号：WO2005016340A1

  公开（公告）日：2005-02-24

  The invention relates to a method of treating with furanone derivatives and the pharmaceutically acceptable salts thereof, one or more conditions of the skin, in particular regulating skin condition, regulating signs of skin aging, treating a number of conditions such as contact dermatitis, skin irritation, rosacea, acne, psoriasis, and preventing and protecting skin tissue against age-related damage or damage resulting from insults such as harmful (UV) radiation or environmental pollution, stress and fatigue.