heptyl 2,3,4,6-tetra-O-[3-(hydroxythioethyl)propyl]-α-D-mannopyranoside | 1234565-56-0

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: heptyl 2,3,4,6-tetra-O-[3-(hydroxythioethyl)propyl]-α-D-mannopyranoside
• CAS: 1234565-56-0
• 化学式: C₃₃H₆₆O₁₀S₄
• 分子量: 751.145
• InChiKey: IFVYEECIUYZXNF-AALIFHQRSA-N

反应信息

• 作为产物：
  描述：

  、 2-巯基乙醇 在 偶氮二异丁腈 作用下， 以 1,4-二氧六环 为溶剂， 以84%的产率得到heptyl 2,3,4,6-tetra-O-[3-(hydroxythioethyl)propyl]-α-D-mannopyranoside
  参考文献：
  名称：

  Synthesis, CI-MS Analyses and Preliminary Biological Evaluation of a Novel Library of Hydrophobic Persulfide-Spacers α-Alkyl Glycosides

  摘要：

  We report the synthesis of novel polyether-based polyols derived from simple glycosides that bear sulfur spacers in the attempt to potentially provide new antibiotics. The CI-MS demonstrated the stepwise and successive fission of the sulfide-spacer groups; however, it does not distinguish between the alditols having different arrangement of O(CH2)(3)-S(CH2)(2)OH groups. The investigated compounds exhibited antimicrobial activities against Staphylococcus aureus, Pseudomonas aeruginosa, Escherichia coli and antifungal activities against Candida albicans at a concentration of 1 mg / ml in DMF.

  DOI：

  10.2174/157017810790796372