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N',N'''-methylethanediylidene-bis-thiophosphorohydrazidic acid tetra-O-ethyl ester | 59895-87-3

中文名称
——
中文别名
——
英文名称
N',N'''-methylethanediylidene-bis-thiophosphorohydrazidic acid tetra-O-ethyl ester
英文别名
——
<i>N</i>',<i>N</i>'''-methylethanediylidene-bis-thiophosphorohydrazidic acid tetra-<i>O</i>-ethyl ester化学式
CAS
59895-87-3
化学式
C11H26N4O4P2S2
mdl
——
分子量
404.431
InChiKey
IOWJXMJCSWXEHL-UHFFFAOYSA-N
BEILSTEIN
——
EINECS
——
  • 物化性质
  • 计算性质
  • ADMET
  • 安全信息
  • SDS
  • 制备方法与用途
  • 上下游信息
  • 反应信息
  • 文献信息
  • 表征谱图
  • 同类化合物
  • 相关功能分类
  • 相关结构分类

计算性质

  • 辛醇/水分配系数(LogP):
    3.12
  • 重原子数:
    23.0
  • 可旋转键数:
    13.0
  • 环数:
    0.0
  • sp3杂化的碳原子比例:
    0.82
  • 拓扑面积:
    85.7
  • 氢给体数:
    2.0
  • 氢受体数:
    8.0

反应信息

  • 作为产物:
    参考文献:
    名称:
    Phosphorus-nitrogen compounds. 20. Thiophosphorus hydrazones
    摘要:
    Six pyridine-2-carboxaldehyde, one pyridine N-oxide 2-carboxaldehyde, and five diketone thiophosphoric hydrazones, three thiophosphoric hydrazides, and two cupric chelates were synthesized. The chelates and nine of the hydrazones were tested against Ehrlich ascites carcinoma. Seven of these latter agents were administered concurrently with either cupric and/or ferrous salts to mice bearing this tumor. The greatest activity was found with the chelate, cimethyl pyridine-2-carboxyaldehyde phosphorothioic hydrazone-copper (1:1). The hydrazone portion of this chelate also formed a ligand-copper (2:1) complex. Although all of the hydrazones but one were inactive when evaluated alone, the concurrent injection of cupric ion increased survival times by an avoli alkaline phosphatase was found to be inhibited by two thiosemicarbazones in a manner similar to that previously reported by these agents against alkaline phosphatase derived from Sarcoma 180-6-thiopurine resistant ascites cells. None of the 14 hydrazides or hydrazones tested against E. coli enzyme displayed significant inhibition.
    DOI:
    10.1021/jm00231a010
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