1-allyl-5-bromo-3-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidene)-1,3-dihydro-indol-2-one | 381206-76-4

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吲哚及其衍生物
• 英文名称: 1-allyl-5-bromo-3-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidene)-1,3-dihydro-indol-2-one
• 英文别名: 5-(5-Bromo-2-oxo-1-prop-2-enylindol-3-ylidene)-2-piperidin-1-yl-1,3-thiazol-4-one
• CAS: 381206-76-4
• 化学式: C₁₉H₁₈BrN₃O₂S
• 分子量: 432.341
• InChiKey: FCJQAUHEUISANT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  26
• 可旋转键数：
  3
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.32
• 拓扑面积：
  78.3
• 氢给体数：
  0
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  哌啶 、 罗丹宁 、 1-烯丙基-5-溴二氢吲哚-2,3-二酮 在 heterogeneous silica supported pyridine catalyst 作用下， 以 乙醇 、 水 为溶剂， 以72%的产率得到1-allyl-5-bromo-3-(4-oxo-2-piperidin-1-yl-4H-thiazol-5-ylidene)-1,3-dihydro-indol-2-one
  参考文献：
  名称：

  Synthesis of molecular scaffolds assimilating both indolinone and thiazolidinone moieties under environmentally benevolent conditions

  摘要：

  A chromatography free synthesis of 2-amino-5-isatinylidenethiazol-4-ones from rhodanine, isatin, and amine under environmentally benevolent conditions is reported for the first time. The molecular scaffolds assimilating both indolinone and thiazolidinone moieties are reported to have great biological significance. (C) 2013 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetlet.2013.07.052

文献信息

• Synthesis of molecular scaffolds assimilating both indolinone and thiazolidinone moieties under environmentally benevolent conditions
  作者：Suman Ray、Chhanda Mukhopadhyay

  DOI：10.1016/j.tetlet.2013.07.052

  日期：2013.9

  A chromatography free synthesis of 2-amino-5-isatinylidenethiazol-4-ones from rhodanine, isatin, and amine under environmentally benevolent conditions is reported for the first time. The molecular scaffolds assimilating both indolinone and thiazolidinone moieties are reported to have great biological significance. (C) 2013 Elsevier Ltd. All rights reserved.