(S)-5-oxopyrrolidine-2-carboxylic acid ethyl ester | 121873-15-2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (S)-5-oxopyrrolidine-2-carboxylic acid ethyl ester
• 英文别名: unifide；(2S)-5-oxo-N-(pyridin-2-ylmethyl)pyrrolidine-2-carboxamide
• CAS: 121873-15-2
• 化学式: C₁₁H₁₃N₃O₂
• 分子量: 219.243
• InChiKey: LLDCPXHOZIQGME-VIFPVBQESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.6
• 重原子数：
  16
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.36
• 拓扑面积：
  71.1
• 氢给体数：
  2
• 氢受体数：
  3

反应信息

• 作为产物：
  描述：

  2-氨甲基吡啶 、 L-焦谷氨酸乙酯 以 乙酸乙酯 为溶剂， 反应 48.0h， 以85%的产率得到(S)-5-oxopyrrolidine-2-carboxylic acid ethyl ester
  参考文献：
  名称：

  New chiral diamide ligands: synthesis and application in allylic alkylation

  摘要：

  A new family of chiral diamide ligands has been designed and synthesised. These ligands have been successfully applied to an asymmetric allylic substitution reaction. A palladium complex of one of the diamide ligands achieved enantio selectivities of up to 93% in the allylic alkylation of 1,3-diphenyl-3-acetoxyprop-1-ene. (C) 2008 Elsevier Ltd. All rights reserved.

  DOI：

  10.1016/j.tetasy.2008.01.018

文献信息

• New chiral diamide ligands: synthesis and application in allylic alkylation
  作者：Lorraine Bateman、Simon W. Breeden、Patrick O’Leary

  DOI：10.1016/j.tetasy.2008.01.018

  日期：2008.2

  A new family of chiral diamide ligands has been designed and synthesised. These ligands have been successfully applied to an asymmetric allylic substitution reaction. A palladium complex of one of the diamide ligands achieved enantio selectivities of up to 93% in the allylic alkylation of 1,3-diphenyl-3-acetoxyprop-1-ene. (C) 2008 Elsevier Ltd. All rights reserved.